Evidence map›Paper›PMID 35882493›Full record

ReviewClinical medicine (London, England)2022

Physiological changes from ageing regarding pain perception and its impact on pain management for older adults.

Sophie Mullins, Faroakh Hosseini, William Gibson, Miriam Thake

Registry-linked trialAbstract readReview
In one paragraph

Review in Clinical medicine (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07421674 (Application Research of Hydromorphinone Sustained-release Tablets in the Treatment of Elderly Patients With Cancer Pain Accompanied by Renal Insufficiency), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07421674 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Application Research of Hydromorphinone Sustained-release Tablets in the Treatment of Elderly Patients With Cancer Pain Accompanied by Renal Insufficiency

Typeobservational_patient_registrySponsorTaian Cancer HospitalRan2026 to 2028Enrolled62ConditionsCancer Pain, Renal Insufficiency Chronic, Hydromorphone Use
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Impact of enhanced recovery after surgery (ERAS) protocols in elderly patients undergoing lumbar fusion: a systematic review with meta-analysis and trial sequential analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Health-related quality of life in cancer survivors aged 65 and older: impact of diagnosis and treatment and perceived decline associated with aging.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sophie MullinsUniversity Hospitals of Bristol and Weston NHS Foundation Trust, Bristol, UK.
Faroakh HosseiniUniversity Hospitals of Bristol and Weston NHS Foundation Trust, Bristol, UK.
William GibsonUniversity of Alberta, Edmonton, Canada.
Miriam ThakeUniversity Hospitals of Bristol and Weston NHS Foundation Trust, Bristol, UK miriam.thake@nhs.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physiological changes that occur during ageing can affect the incidence, experience and treatment of pain in older adults. This article reviews these physiological changes and how they can affect the best approach to management.

Indexed as

PainPain ManagementAgedAgingHumansPain Perceptionageingneuropathicnociceptivepainpharmacodynamics

Identifiers

PMID35882493
PMCPMC9345212

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.