Evidence map›Paper›PMID 35882478›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Effects of prenatal alcohol exposure on neurobehavioural development and volume of rostral cingulate cortex subregions.

Arash Aghamohammadi-Sereshki, Carly A McMorris, W Ben Gibbard, Christina Tortorelli, G Bruce Pike, Catherine Lebel

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Arash Aghamohammadi-SereshkiFrom the Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alta. (Aghamohammadi-Sereshki, Pike, Lebel); the Alberta Children's Hospital Research Institute, Calgary, Alta. (McMorris, Gibbard, Lebel); the Werklund School of Education, University of Calgary, Calgary, Alta. (McMorris); the Department of Pediatrics, University of Calgary, Calgary, Alta. (Gibbard); the Department of Child Studies and Social Work, Mount Royal University, Calgary, Alta. (Tortorelli); the Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Alta. (Pike); the Hotchkiss Brain Institute, University of Calgary, Calgary, Alta. (Pike, Lebel) clebel@ucalgary.ca aghamoha@ualberta.ca.
Carly A McMorrisFrom the Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alta. (Aghamohammadi-Sereshki, Pike, Lebel); the Alberta Children's Hospital Research Institute, Calgary, Alta. (McMorris, Gibbard, Lebel); the Werklund School of Education, University of Calgary, Calgary, Alta. (McMorris); the Department of Pediatrics, University of Calgary, Calgary, Alta. (Gibbard); the Department of Child Studies and Social Work, Mount Royal University, Calgary, Alta. (Tortorelli); the Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Alta. (Pike); the Hotchkiss Brain Institute, University of Calgary, Calgary, Alta. (Pike, Lebel).
W Ben GibbardFrom the Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alta. (Aghamohammadi-Sereshki, Pike, Lebel); the Alberta Children's Hospital Research Institute, Calgary, Alta. (McMorris, Gibbard, Lebel); the Werklund School of Education, University of Calgary, Calgary, Alta. (McMorris); the Department of Pediatrics, University of Calgary, Calgary, Alta. (Gibbard); the Department of Child Studies and Social Work, Mount Royal University, Calgary, Alta. (Tortorelli); the Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Alta. (Pike); the Hotchkiss Brain Institute, University of Calgary, Calgary, Alta. (Pike, Lebel).
Christina TortorelliFrom the Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alta. (Aghamohammadi-Sereshki, Pike, Lebel); the Alberta Children's Hospital Research Institute, Calgary, Alta. (McMorris, Gibbard, Lebel); the Werklund School of Education, University of Calgary, Calgary, Alta. (McMorris); the Department of Pediatrics, University of Calgary, Calgary, Alta. (Gibbard); the Department of Child Studies and Social Work, Mount Royal University, Calgary, Alta. (Tortorelli); the Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Alta. (Pike); the Hotchkiss Brain Institute, University of Calgary, Calgary, Alta. (Pike, Lebel).
G Bruce PikeFrom the Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alta. (Aghamohammadi-Sereshki, Pike, Lebel); the Alberta Children's Hospital Research Institute, Calgary, Alta. (McMorris, Gibbard, Lebel); the Werklund School of Education, University of Calgary, Calgary, Alta. (McMorris); the Department of Pediatrics, University of Calgary, Calgary, Alta. (Gibbard); the Department of Child Studies and Social Work, Mount Royal University, Calgary, Alta. (Tortorelli); the Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Alta. (Pike); the Hotchkiss Brain Institute, University of Calgary, Calgary, Alta. (Pike, Lebel).
Catherine LebelFrom the Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alta. (Aghamohammadi-Sereshki, Pike, Lebel); the Alberta Children's Hospital Research Institute, Calgary, Alta. (McMorris, Gibbard, Lebel); the Werklund School of Education, University of Calgary, Calgary, Alta. (McMorris); the Department of Pediatrics, University of Calgary, Calgary, Alta. (Gibbard); the Department of Child Studies and Social Work, Mount Royal University, Calgary, Alta. (Tortorelli); the Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Alta. (Pike); the Hotchkiss Brain Institute, University of Calgary, Calgary, Alta. (Pike, Lebel) clebel@ucalgary.ca aghamoha@ualberta.ca.
Alberta Children's Hospital Research InstituteMount Royal University · CAAlberta Children's Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMaternal alcohol consumption during pregnancy can have widespread and long-lasting effects on children's cognition, behaviour, brain function and structure. The pregenual anterior cingulate cortex (ACC) and the anterior midcingulate cortex (MCC) mediate emotional and cognitive behaviours that are affected by prenatal alcohol exposure. However, the neurobehavioural development of the pregenual ACC and anterior MCC has not been examined in people with prenatal alcohol exposure.

methodsWe recruited 30 children and adolescents with prenatal alcohol exposure and 50 age- and gender-matched unexposed controls. We acquired structural MRI data sets on a 3 T scanner. We manually delineated 2 areas of the rostral cingulate cortex - the pregenual ACC and the anterior MCC - and compared them between groups. We measured behavioural and emotional problems using the Behaviour Assessment System for Children, 2nd Edition, Parent Rating Scale, and then explored their associations with rostral cingulate cortex volumes.

resultsIntracranial-normalized volumes of the right pregenual ACC and the right total rostral cingulate cortex were significantly smaller in individuals with prenatal alcohol exposure than in unexposed controls. The volume of the right anterior MCC had a significant positive association with scores on the Internalizing Problems scale in individuals with prenatal alcohol exposure. LIMITATIONS: This study was cross-sectional, and detailed information about the timing and amount of exposure was not always available.

conclusionPrenatal alcohol exposure is associated with lower volumes in the right pregenual ACC. This finding may underlie some of the emotional and behavioural problems experienced by individuals with prenatal alcohol exposure.

Indexed as

Gyrus CinguliPrenatal Exposure Delayed EffectsAdolescentChildCross-Sectional StudiesEmotionsFemaleHumansMagnetic Resonance ImagingPregnancy

Identifiers

PMID35882478
PMCPMC9337872
OpenAlexW4288036863

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.