Evidence map›Paper›PMID 35882349›Full record

ArticleNature2022

Discovery, structure and mechanism of a tetraether lipid synthase.

Cody T Lloyd, David F Iwig, Bo Wang, Matteo Cossu, William W Metcalf, Amie K Boal, Squire J Booker

Abstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Mechanistic insight into radicalNatural product reports · 2026
    Review
  2. Identification ofApplied and environmental microbiology · 2026
    Article
  3. Review
  4. Ocean warming enhances iron use efficiencies of marine ammonia-oxidizing archaea.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Novel Extended Tetraether Lipids Found in a High-COEnvironmental microbiology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Cyclization of archaeal membrane lipids impacts membrane protein activity and archaellum formation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Chemiosmotic ATP synthesis by minimal protocells.Cell reports. Physical science · 2025
    Article
  13. Article
  14. Iron-sulfur clusters: the road to room temperature.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Review
  15. Review
  16. Review
  17. The Archaeal Cell Cycle.Annual review of cell and developmental biology · 2024
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cody T LloydDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA.
David F IwigThe Howard Hughes Medical Institute, Pennsylvania State University, University Park, PA, USA.
Bo WangThe Howard Hughes Medical Institute, Pennsylvania State University, University Park, PA, USA.
Matteo CossuDepartment of Microbiology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
William W MetcalfDepartment of Microbiology, University of Illinois Urbana-Champaign, Urbana, IL, USA.ORCID http://orcid.org/0000-0002-0182-0671
Amie K BoalDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA. akb20@psu.edu.
Squire J BookerDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA. squire@psu.edu.ORCID http://orcid.org/0000-0002-7211-5937

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6M
Mapping the Structural Basis for Mechanistic Diversity in Metalloenzyme SuperfamiliesR35GM119707 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Amie K Boal · 2016 to 2026
$5.0M
Radical Mechanisms of Iron-Sulfur ProteinsR35GM122595 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI SQUIRE J. BOOKER · 2017 to 2026
$3.4M
High-Speed High-Sensitivity Detector for X-ray Micro-Crystallography at GM/CA@APSS10OD012289 · OD · UNIVERSITY OF CHICAGO · PI FISCHETTI, ROBERT F. · 2014 to 2014
$2.0M
Howard Hughes Medical InstituteNIGMS NIH HHS P30 GM124169NIGMS NIH HHS R35 GM119707NIGMS NIH HHS R35 GM122595NIH HHS S10 OD012289
6 · The paper itself

Abstract

Archaea synthesize isoprenoid-based ether-linked membrane lipids, which enable them to withstand extreme environmental conditions, such as high temperatures, high salinity, and low or high pH values

Indexed as

Archaeal ProteinsGlyceryl EthersMembrane LipidsMethanocaldococcusCarbonGlycerolS-AdenosylmethionineTerpenesArchaeal ProteinsCarbonGlycerolGlyceryl EthersMembrane LipidsS-AdenosylmethionineTerpenes

Identifiers

PMID35882349
PMCPMC9433317

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.