Evidence map›Paper›PMID 35882030›Full record

ArticleJournal of glaucoma2022

Effects of Smoking on Optic Nerve Head Microvasculature Density in Glaucoma.

Medi Eslani, Takashi Nishida, Robert N Weinreb, Sally Baxter, Golnoush Mahmoudinezhad, Alireza Kamalipour, Adeleh Yarmohammadi, Linda M Zangwill, Sasan Moghimi

Open access · greenAbstract read
In one paragraph

Article in Journal of glaucoma, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Observational
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Medi EslaniHamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology.
Takashi NishidaHamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology.
Robert N WeinrebHamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology.
Sally BaxterHamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology.
Golnoush MahmoudinezhadHamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology.
Alireza KamalipourHamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology.
Adeleh YarmohammadiHamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology.
Linda M ZangwillHamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology.
Sasan MoghimiHamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology.
University of California, San Diego · US

Funding

Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Derek Stuart Welsbie · 2012 to 2026
$10.3M
Diagnostic Innovations in Glaucoma:Structural AssessmentR01EY011008 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 1995 to 2015
$8.7M
xADAGES III: Contribution of genotype to glaucoma phenotype in African AmericansR01EY023704 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROTTER, JEROME I, WEINREB, ROBERT N · 2013 to 2017
$6.3M
Diagnostic Innovations in Glaucoma Study (DIGS): High Myopia and Advanced DiseaseR01EY027510 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2017 to 2026
$5.3M
Diagnosis and Monitoring of Glaucoma with Optical Coherence Tomography AngiographyR01EY029058 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WEINREB, ROBERT N · 2018 to 2024
$4.2M
African Descent and Glaucoma Evaluation (ADAGES) IV: Alterations of the lamina cribrosa in progressionR01EY026574 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FAZIO, MASSIMO ANTONIO, GIRKIN, CHRISTOPHER ANTHONY · 2017 to 2020
$2.6M
Monitoring of Glaucoma Patients in Advanced DiseaseR01EY034148 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sasan Moghimi Araghi · 2022 to 2026
$2.5M
Multi-modal Health Information Technology Innovations for Precision Management of GlaucomaDP5OD029610 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAXTER, SALLY LIU · 2020 to 2024
$2.1M
NEI NIH HHS P30 EY022589NEI NIH HHS R01 EY011008NEI NIH HHS R01 EY023704NEI NIH HHS R01 EY026574NEI NIH HHS R01 EY027510NEI NIH HHS R01 EY029058NEI NIH HHS R01 EY034148NIH HHS DP5 OD029610
6 · The paper itself

Abstract

prcisDecreased superficial whole image capillary density was observed in open angle glaucoma (OAG) patients with high smoking intensity. PURPOSE: To investigate the effects of smoking on optic nerve head capillary density measured by optical coherence tomography angiography in patients with OAG.

methodsIn this retrospective cross-sectional study, perimetric and preperimetric glaucoma patients enrolled in the Diagnostic Innovations in Glaucoma Study (DIGS) with optical coherence tomography angiography follow-up were included. Univariable and multivariable linear mixed analysis were performed to determine the effects of different variables on the superficial whole image capillary density.

resultsA total of 432 eyes of 271 glaucoma patients comprising 63 preperimetric (106 eyes) and 208 perimetric OAG (326 eyes) were included. A history of tobacco consumption was reported in 105 (38.8%). Among smokers, mean (95% confidence interval) smoking intensity was 12.8 (10.2, 15.5) pack-years. After adjusting for age, glaucoma severity and other confounders, each 10 pack-year increase in smoking intensity (95% confidence interval) was associated with -0.54 (-1.06, -0.02) % lower whole image capillary density ( P =0.041).

conclusionsSmoking intensity is associated with reduced optic nerve vessel density in glaucoma.

Indexed as

GlaucomaGlaucoma, Open-AngleOptic DiskCapillariesCross-Sectional StudiesFluorescein AngiographyHumansIntraocular PressureRetinal VesselsRetrospective StudiesSmokingTomography, Optical CoherenceVisual Fields

Identifiers

PMID35882030
PMCPMC9994055
OpenAlexW4288044043

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.