Evidence map›Paper›PMID 35881934›Full record

ArticleNano letters2022

Ultra-photostable DNA FluoroCubes: Mechanism of Photostability and Compatibility with FRET and Dark Quenching.

Aaron T Blanchard, Zi Li, Elizabeth C Duran, Catherine E Scull, J Damon Hoff, Keenan R Wright, Victor Pan, Nils G Walter

Erratum issuedAbstract read
In one paragraph

Article in Nano letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Traction Force Microscopy with DNA FluoroCubes.Langmuir : the ACS journal of surfaces and colloids · 2026
    Article
  2. Reactive oxygen species-resistant ultrastable super-resolution DNA framework dots.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Thioether editing generally increases the photostability of rhodamine dyes on self-labeling tags.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Aaron T BlanchardSingle Molecule Analysis Group, Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-3129-6591
Zi LiSingle Molecule Analysis Group, Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
Elizabeth C DuranSingle Molecule Analysis Group, Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
Catherine E ScullSingle Molecule Analysis Group, Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
J Damon HoffSingle Molecule Analysis in Real-Time (SMART) Center, University of Michigan, Ann Arbor, Michigan 48109, United States.
Keenan R WrightDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
Victor PanDepartment of Biomedical Engineering, Emory University and the Georgia Institute of Technology, Atlanta, Georgia, 30322.
Nils G WalterSingle Molecule Analysis Group, Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-7301-1275

Funding

Michigan IRACDA: Training Future Professors of Engineering and PhysiologyK12GM111725 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROOKS, SUSAN V, SEPT, DAVID · 2016 to 2025
$7.9M
The RNA nanomachines of the gene expression machinery dissected at the single molecule levelR35GM131922 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NILS G WALTER · 2019 to 2026
$6.9M
Optimization and Validation of Single-Molecule Kinetic Fingerprinting Technology for Rapid, Ultra-Specific Detection of Cancer MutationsR33CA229023 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TEWARI, MUNEESH, WALTER, NILS G · 2018 to 2020
$1.2M
Single-molecule counting of cancer biomarker miRNAs in human biofluidsR21CA204560 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WALTER, NILS G · 2017 to 2019
$614k
The mechanical role of the glycocalyx in cancer cell adhesionK00CA245789 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BLANCHARD, AARON · 2020 to 2024
$369k
Dynamics of co-transcriptional riboswitch folding through single-molecule microscopyF32GM140547 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCULL, CATHERINE · 2021 to 2022
$78k
NCI NIH HHS K00 CA245789NCI NIH HHS R21 CA204560NCI NIH HHS R33 CA229023NIGMS NIH HHS F32 GM140547NIGMS NIH HHS K12 GM111725NIGMS NIH HHS R35 GM131922
6 · The paper itself

Abstract

DNA-based FluoroCubes were recently developed as a solution to photobleaching, a ubiquitous limitation of fluorescence microscopy (Niekamp; ; Stuurman; ; Vale

Indexed as

Fluorescence Resonance Energy TransferFluorescent DyesDNAMicroscopy, FluorescencePhotobleachingDNAFluorescent DyesDNA nanotechnologyfluorescence microscopyfluorogenic probesFRETsingle molecule imaging

Identifiers

PMID35881934
PMCPMC10080265

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.