Evidence map›Paper›PMID 35881801›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

PRD-2 mediates clock-regulated perinuclear localization of clock gene RNAs within the circadian cycle of

Bradley M Bartholomai, Amy S Gladfelter, Jennifer J Loros, Jay C Dunlap

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
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  5. Article
  6. Article
  7. PERspectives on circadian cell biology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Regulation of circadian rhythms by clock protein nuclear bodies.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Bradley M BartholomaiDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.ORCID 0000-0002-3082-3425
Amy S GladfelterDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Jennifer J LorosDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.ORCID 0000-0003-0451-2858
Jay C DunlapDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.ORCID 0000-0003-1577-0457
Dartmouth College · USUniversity of North Carolina at Chapel Hill · US

Funding

Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MADDEN, DEAN R · 2016 to 2025
$25.9M
Genetic and Molecular Dissection of the Neurospora ClockR35GM118021 · NIGMS · DARTMOUTH COLLEGE · PI Jay C. Dunlap · 2016 to 2026
$7.3M
Molecular and Cellular Biology at DartmouthT32GM008704 · NIGMS · DARTMOUTH COLLEGE · PI COMPTON, DUANE A. · 1998 to 2018
$6.8M
Identification and Analysis of Circadian Clock-Controlled GenesR35GM118022 · NIGMS · DARTMOUTH COLLEGE · PI LOROS, JENNIFER J. · 2016 to 2021
$3.7M
NIGMS NIH HHS P20 GM113132NIGMS NIH HHS R35 GM118021NIGMS NIH HHS R35 GM118022NIGMS NIH HHS T32 GM008704
6 · The paper itself

Abstract

The transcription-translation negative feedback loops underlying animal and fungal circadian clocks are remarkably similar in their molecular regulatory architecture and, although much is understood about their central mechanism, little is known about the spatiotemporal dynamics of the gene products involved. A common feature of these circadian oscillators is a significant temporal delay between rhythmic accumulation of clock messenger RNAs (mRNAs) encoding negative arm proteins, for example,

Indexed as

Circadian ClocksCircadian RhythmCLOCK ProteinsFungal ProteinsNeurospora crassaPeriod Circadian ProteinsRNA, MessengerIn Situ Hybridization, FluorescenceTranscription, GeneticCLOCK ProteinsFungal ProteinsPeriod Circadian ProteinsRNA, Messengercell biologycircadian rhythmsliquid–liquid phase separationNeurosporasmFISH

Identifiers

PMID35881801
PMCPMC9351534
OpenAlexW4288036165

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.