Evidence map›Paper›PMID 35881790›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

A missense mutation in

Pin Xu, Kazuhiro Shimomura, Changhoon Lee, Xiaofei Gao, Eleanor H Simpson, Guocun Huang, Chryshanthi M Joseph, Vivek Kumar, Woo-Ping Ge, Karen S Pawlowski and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Pin XuDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Kazuhiro ShimomuraDepartment of Neurobiology, Northwestern University, Evanston, IL 60208.ORCID 0000-0002-9089-7485
Changhoon LeeDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Xiaofei GaoChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Eleanor H SimpsonDepartment of Psychiatry, Columbia University, New York, NY 10032.ORCID 0000-0002-9092-2230
Guocun HuangDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Chryshanthi M JosephDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Vivek KumarDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0001-6643-7465
Woo-Ping GeDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Karen S PawlowskiDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9152.
Mitchell D FryeDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Saïd KourrichDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Eric R KandelDepartment of Psychiatry, Columbia University, New York, NY 10032.ORCID 0000-0001-7851-6902
Joseph S TakahashiDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-0384-8878
The University of Texas Southwestern Medical Center · USChildren's Medical Center · USColumbia University · USNorthwestern University · USResearch Foundation For Mental Hygiene · US

Funding

Mouse Mutagenesis: Phenotype-Driven Neuroscience ScreensU01MH061915 · NIMH · NORTHWESTERN UNIVERSITY · PI TAKAHASHI, JOSEPH S · 2001 to 2005
$29.1M
Howard Hughes Medical InstituteNIMH NIH HHS U01 MH061915
6 · The paper itself

Abstract

Although a wide variety of genetic tools has been developed to study learning and memory, the molecular basis of memory encoding remains incompletely understood. Here, we undertook an unbiased approach to identify novel genes critical for memory encoding. From a large-scale, in vivo mutagenesis screen using contextual fear conditioning, we isolated in mice a mutant, named

Indexed as

HippocampusLearning DisabilitiesMemoryMutation, MissenseShaw Potassium ChannelsAction PotentialsAnimalsMiceMice, Inbred C57BLKcnc3 protein, mouseShaw Potassium Channelsbehavioral screenENU mutagenesishippocampuslearning and memorypotassium channels

Identifiers

PMID35881790
PMCPMC9351536
OpenAlexW4288036220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.