Evidence map›Paper›PMID 35881632›Full record

ArticlePloS one2022

The role of solar and geomagnetic activity in endothelial activation and inflammation in the NAS cohort.

Jessica E Schiff, Carolina L Z Vieira, Eric Garshick, Veronica Wang, Annelise Blomberg, Diane R Gold, Joel Schwartz, Samantha M Tracy, Pantel Vokonas, Petros Koutrakis

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jessica E SchiffDepartment of Environmental Health, Harvard T.H. Chan School of Public Heath, Boston, MA, United States of America.ORCID 0000-0001-7916-5366
Carolina L Z VieiraDepartment of Environmental Health, Harvard T.H. Chan School of Public Heath, Boston, MA, United States of America.
Eric GarshickPulmonary, Allergy, Sleep, and Critical Care Medicine Section, VA Boston Healthcare System, Boston, MA, United States of America.
Veronica WangDepartment of Environmental Health, Harvard T.H. Chan School of Public Heath, Boston, MA, United States of America.
Annelise BlombergDepartment of Environmental Health, Harvard T.H. Chan School of Public Heath, Boston, MA, United States of America.ORCID 0000-0003-1360-2580
Diane R GoldProfessor of Medicine, Harvard Medical School, Boston, MA, United States of America.
Joel SchwartzDepartment of Environmental Health, Harvard T.H. Chan School of Public Heath, Boston, MA, United States of America.
Samantha M TracyDepartment of Environmental Health, Harvard T.H. Chan School of Public Heath, Boston, MA, United States of America.
Pantel VokonasVA Normative Aging Study, Veterans Affairs Boston Healthcare System and the Department of Medicine, Boston University School of Medicine, Boston, MA, United States of America.
Petros KoutrakisDepartment of Environmental Health, Harvard T.H. Chan School of Public Heath, Boston, MA, United States of America.
Harvard University · USBoston University · USBrigham and Women's Hospital · US

Funding

Retrospective assessment of radon progeny and pollution effects in COPDR21ES029637 · NIEHS · HARVARD MEDICAL SCHOOL · PI GARSHICK, ERIC · 2019 to 2020
$453k
NIEHS NIH HHS R21 ES029637
6 · The paper itself

Abstract

This study investigated the associations between solar and geomagnetic activity and circulating biomarkers of systemic inflammation and endothelial activation in the Normative Aging Study (NAS) cohort. Mixed effects models with moving day averages from day 0 to day 28 were used to study the associations between solar activity (sunspot number (SSN), interplanetary magnetic field (IMF)), geomagnetic activity (planetary K index (Kp index), and various inflammatory and endothelial markers. Biomarkers included intracellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), C-reactive protein (CRP), and fibrinogen. After adjusting for demographic and meteorological variables, we observed significant positive associations between sICAM-1 and sVCAM-1 concentrations and solar and geomagnetic activity parameters: IMF, SSN, and Kp. Additionally, a negative association was observed between fibrinogen and Kp index and a positive association was observed for CRP and SSN. These results demonstrate that solar and geomagnetic activity might be upregulating endothelial activation and inflammation.

Indexed as

Intercellular Adhesion Molecule-1Vascular Cell Adhesion Molecule-1BiomarkersC-Reactive ProteinFibrinogenHumansInflammationPlant ExtractsBiomarkersC-Reactive ProteinFibrinogenIntercellular Adhesion Molecule-1nasPlant ExtractsVascular Cell Adhesion Molecule-1

Identifiers

PMID35881632
PMCPMC9321765
OpenAlexW4288039992

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.