ArticlePloS one2022
Oropouche virus infection in patients with acute febrile syndrome: Is a predictive model based solely on signs and symptoms useful?
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Pooled it
- Oropouche virus infection: clinical spectrum, geographic expansion, and emerging maternal-fetal implications.Infection · 2026Review
- Epidemiological investigation of Shuni virus infections in hospitals in two provinces of South Africa (2019-2021) using molecular and serological surveillance.PLoS neglected tropical diseases · 2026Article
- Enhanced virulence and neuroinvasion of contemporaryFrontiers in microbiology · 2026Article
- The emerging threat of Oropouche virus in Latin America: epidemiology, clinical manifestations, diagnosis, and management.Annals of medicine and surgery (2012) · 2025Review
- Protein-based tools for the detection and characterisation of Oropouche virus infection.EMBO molecular medicine · 2025Article
- Oropouche Virus: The Silent Threat of a Re-emerging Arbovirus.Archives of Razi Institute · 2025Review
- Oropouche Virus Importation in Southern Brazil and Emerging Concern Calling for Enhanced Public Health Surveillance.Journal of medical virology · 2025Article
- The emergence of oropouche fever: A potential new threat?New microbes and new infections · 2025Article
- Global infectious disease early warning models: An updated review and lessons from the COVID-19 pandemic.Infectious Disease Modelling · 2025Review
- Mysterious Oropouche virus: Transmission, symptoms, and control.Infectious medicine · 2025Review
- The Oropouche virus (OROV) and need of advanced diagnostics to mitigate it.Annals of medicine and surgery (2012) · 2025Article
- Addressing the emerging threat of Oropouche virus: implications and public health responses for healthcare systems.Tropical diseases, travel medicine and vaccines · 2025Review
- Oropouche fever outbreak in Brazil: Key factors behind the largest epidemic in history.PloS one · 2025Article
- Insights into the expansion of Oropouche virus in Brazil: epidemiological and environmental aspects.Experimental biology and medicine (Maywood, N.J.) · 2025Review
- Human outbreaks of a novel reassortant Oropouche virus in the Brazilian Amazon region.Nature medicine · 2024Article
- Oropouche Virus: An Emerging Neuroinvasive Arbovirus.Annals of neurology · 2024Review
- Oropouche fever fatalities and vertical transmission in South America: implications of a potential new mode of transmission.Lancet regional health. Americas · 2024Article
- Oropouche Virus: An Emerging Orthobunyavirus.The Journal of general virology · 2024Review
- Oropouche Virus Disease Among U.S. Travelers - United States, 2024.MMWR. Morbidity and mortality weekly report · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOropouche fever is an infectious disease caused by the Oropouche virus (OROV). The diagnosis and prediction of the clinical picture continue to be a great challenge for clinicians who manage patients with acute febrile syndrome. Several symptoms have been associated with OROV virus infection in patients with febrile syndrome; however, to date, there is no clinical prediction rule, which is a fundamental tool to help the approach of this infectious disease.
objectiveTo assess the performance of a prediction model based solely on signs and symptoms to diagnose Oropouche virus infection in patients with acute febrile syndrome. MATERIALS AND
methodsValidation study, which included 923 patients with acute febrile syndrome registered in the Epidemiological Surveillance database of three arbovirus endemic areas in Peru.
resultsA total of 97 patients (19%) were positive for OROV infection in the development group and 23.6% in the validation group. The area under the curve was 0.65 and the sensitivity, specificity, PPV, NPV, LR + and LR- were 78.2%, 35.1%, 27.6%, 83.6%, 1.20 and 0.62, respectively.
conclusionsThe development of a clinical prediction model for the diagnosis of Oropouche based solely on signs and symptoms does not work well. This may be due to the fact that the symptoms are nonspecific and related to other arbovirus infections, which confuse and make it difficult to predict the diagnosis, especially in endemic areas of co-infection of these diseases. For this reason, epidemiological surveillance of OROV in various settings using laboratory tests such as PCR is important.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.