Evidence map›Paper›PMID 35881539›Full record

ArticleThe Journal of clinical endocrinology and metabolism2022

Thyroid Cancer and Pesticide Use in a Central California Agricultural Area: A Case Control Study.

Negar Omidakhsh, Julia E Heck, Myles Cockburn, Chenxiao Ling, Jerome M Hershman, Avital Harari

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Negar OmidakhshDepartment of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-1543-0313
Julia E HeckCollege of Health and Public Service, University of North Texas, Denton, TX, USA.
Myles CockburnDepartment of Preventative Medicine, Keck School of Medicine and Department of Geography, University of Southern California, Los Angeles, California, USA.
Chenxiao LingDepartment of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.
Jerome M HershmanDepartment of Medicine, Section of Endocrinology, University of California Los Angeles, Los Angeles, CA, USA.
Avital HarariDepartment of Surgery, Section of Endocrine Surgery, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-3133-6327
Los Angeles County Department of Public Health · USUniversity of California, Los Angeles · USUniversity of North Texas · USUniversity of Southern California · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
NIEHS NIH HHS P30 ES007048
6 · The paper itself

Abstract

objectiveTo examine environmental factors that influence risk of thyroid cancer.

methodsWe performed a case-control study utilizing thyroid cancer cases from the California Cancer Registry (1999-2012) and controls sampled in a population-based manner. Study participants were included if they were diagnosed with thyroid cancer, lived in the study area at their time of diagnosis, and were ≥35 years of age. Controls were recruited from the same area and eligible to participate if they were ≥35 years of age and had been living in California for at least 5 years prior to the interview. We examined residential exposure to 29 agricultural use pesticides, known to cause DNA damage in vitro or are known endocrine disruptors. We employed a validated geographic information system-based system to generate exposure estimates for each participant.

resultsOur sample included 2067 cases and 1003 controls. In single pollutant models and within a 20-year exposure period, 10 out of 29 selected pesticides were associated with thyroid cancer, including several of the most applied pesticides in the United States such as paraquat dichloride [odds ratio (OR): 1.46 (95% CI: 1.23, 1.73)], glyphosate [OR: 1.33 (95% CI: 1.12, 1.58)], and oxyfluorfen [OR: 1.21 (95% CI: 1.02, 1.43)]. Risk of thyroid cancer increased proportionately to the total number of pesticides subjects were exposed to 20 years before diagnosis or interview. In all models, paraquat dichloride was associated with thyroid cancer.

conclusionsOur study provides first evidence in support of the hypothesis that residential pesticide exposure from agricultural applications is associated with an increased risk of thyroid cancer.

Indexed as

PesticidesThyroid NeoplasmsCaliforniaCase-Control StudiesEnvironmental ExposureHumansParaquatParaquatPesticidescase-control studyresidential pesticide usethyroid cancer

Identifiers

PMID35881539
PMCPMC12102722
OpenAlexW4288040254

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.