Evidence map›Paper›PMID 35881171›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2022

Muc5b plays a role in the development of inflammation and fibrosis in hypersensitivity pneumonitis induced by

Tsukasa Okamoto, Evgenia Dobrinskikh, Corinne E Hennessy, Naoko Liu, Marvin I Schwarz, Christopher M Evans, Andrew P Fontenot, Ivana V Yang, David A Schwartz

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. How experimental models have unlocked hidden mechanisms of hypersensitivity pneumonitis.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Tsukasa OkamotoDepartment of Medicine, University of Colorado, Aurora, Colorado.ORCID 0000-0002-5998-9939
Evgenia DobrinskikhDepartment of Medicine, University of Colorado, Aurora, Colorado.
Corinne E HennessyDepartment of Medicine, University of Colorado, Aurora, Colorado.
Naoko LiuDepartment of Medicine, University of Colorado, Aurora, Colorado.
Marvin I SchwarzDepartment of Medicine, University of Colorado, Aurora, Colorado.
Christopher M EvansDepartment of Medicine, University of Colorado, Aurora, Colorado.ORCID 0000-0001-5600-7314
Andrew P FontenotDepartment of Medicine, University of Colorado, Aurora, Colorado.
Ivana V YangDepartment of Medicine, University of Colorado, Aurora, Colorado.
David A SchwartzDepartment of Medicine, University of Colorado, Aurora, Colorado.ORCID 0000-0001-6743-8443
University of Colorado Anschutz Medical Campus · USTokyo Medical and Dental University · JP

Funding

Role of Mucin in Lung Homeostasis and PathophysiologyR01HL080396 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Christopher M Evans · 2009 to 2026
$8.6M
Mechanisms of lung macrophage programming by MUC5B during health and diseaseR01HL130938 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI EVANS, CHRISTOPHER M · 2016 to 2025
$5.2M
Genes and Transcripts that Interact with MUC5B in Pulmonary FibrosisR01HL149836 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI CLOUTHIER, DAVID E., SCHWARTZ, DAVID ALBERT · 2020 to 2023
$3.0M
lncRNAs, Linking Genetic Susceptibility to Molecular Phenotype in IPFI01BX005295 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI David Albert Schwartz · 2022 to 2026
–
BLRD VA I01 BX005295NHLBI NIH HHS R01 HL080396NHLBI NIH HHS R01 HL130938NHLBI NIH HHS R01 HL149836
6 · The paper itself

Abstract

Previously we have shown that a gain-of-function

Indexed as

Alveolitis, Extrinsic AllergicIdiopathic Pulmonary FibrosisSaccharopolysporaAnimalsBronchoalveolar Lavage FluidDisease Models, AnimalHumansInflammationMiceMice, Inbred C57BLMucin-5BMUC5B protein, humanMuc5b protein, mouseMucin-5Bfibrosishypersensitivity pneumonitisinflammationMuc5b

Identifiers

PMID35881171
PMCPMC9423777
OpenAlexW4288035074

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.