Evidence map›Paper›PMID 35881009›Full record

ArticleJournal of comparative effectiveness research2022

A plain language summary of the likelihood of symptom relief for patients taking fesoterodine for overactive bladder.

Adrian S Wagg, Sender Herschorn, Martin Carlsson, Mireille Fernet, Matthias Oelke

6 registry-linked trialsOpen access · hybridAbstract readCommentPatient Education Handout
PubMed Publisher
In one paragraph

Article in Journal of comparative effectiveness research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00138723 phase3completednot on this map

A Phase 3, Parallel Group, Randomized, Double-Blind, Placebo Controlled Multicenter Trial to Investigate the Efficacy, Tolerability and Safety of Fesoterodine Sustained Release in Subjects With Overactive Bladder Syndrome

TypeinterventionalSponsorPfizerRan2003 to 2005ConditionsOveractive BladderArmsSPM 907
NCT00220363 phase3completednot on this map

A Phase 3, Parallel Group, Randomized, Double-Blind, Double-Dummy, Placebo and Active-Controlled Multicenter Trial to Investigate the Efficacy, Tolerability and Safety of Fesoterodine Sustained Release in Subjects With Overactive Bladder Syndrome

TypeinterventionalSponsorPfizerRan2004 to 2005ConditionsOveractive Bladder SyndromeArmsSPM 907
NCT00444925 phase3completednot on this map

12-Week, Randomized, Double-Blind, Double-Dummy,Placebo-Controlled, Parallel-Group, Multicenter Trial To Evaluate The Efficacy And Safety Of Fesoterodine In Comparison To Tolterodine ER In Patients With Overactive Bladder (OAB)

TypeinterventionalSponsorPfizerRan2007 to 2008Enrolled1,712ConditionsOveractive BladderArmsfesoterodine fumarate, placebo, tolterodine tartrate
NCT00611026 phase3completednot on this map

12-Week, Randomized, Double-Blind, Double-Dummy, Placebo-Controlled, Parallel-Group, Multicenter Trial To Evaluate The Efficacy And Safety Of Fesoterodine In Comparison To Tolterodine ER In Patients With Overactive Bladder.

TypeinterventionalSponsorPfizerRan2008 to 2009Enrolled2,417ConditionsOveractive BladderArmsTolterodine ER, Placebo, Fesoterodine
NCT01302054 phase4completednot on this map

A 14 Week Randomized Parallel Group Placebo-Controlled Double-Blind Multicentre Study Of Fesoterodine 8 Mg In Overactive Bladder Patients With Sub-Optimal Response To Tolterodine 4 Mg Extended Release (ER).

TypeinterventionalSponsorPfizerRan2011 to 2012Enrolled990ConditionsUrinary Bladder, OveractiveArmsFesoterodine 8 mg, Placebo
NCT01302067 phase4completednot on this map

A 12-Week, Randomized, Double-Blind, Placebo Controlled, Parallel Group, Multicenter Trial In Overactive Bladder Subjects To Confirm The Efficacy Of 8 Mg Fesoterodine Compared To 4 Mg Fesoterodine.

TypeinterventionalSponsorPfizerRan2011 to 2012Enrolled2,012ConditionsOveractive BladderArmsFesoterodine 8mg, Fesoterodine 4mg, Placebo
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Journal of comparative effectiveness research · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 3 countries.

Adrian S WaggDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Sender HerschornDivision of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Martin CarlssonStatistics Lead-Rare Disease/Endocrine, Pfizer Global Product Development, New York, New York, USA.
Mireille FernetMedical Affairs/Affaires Médicales, Pfizer Canada, Montreal, Quebec, Canada.
Matthias OelkeDepartment of Urology, St. Antonius-Hospital, Gronau, Germany.
Pfizer (Canada) · CAPfizer (United States) · USSt.-Antonius-Hospital Gronau · DESunnybrook Health Science Centre · CAUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

WHAT IS THIS SUMMARY ABOUT?: This is a summary of a study originally published in WHAT WERE THE RESULTS?: Although complete resolution of all symptoms was rare with fesoterodine treatment, a resolution of accidental urination was more common, which is the most important treatment goal for many patients. After taking fesoterodine, episodes of accidental urination were more likely to be reduced or completely absent than episodes of an urgent need to urinate. WHAT DO THE RESULTS OF THE STUDY MEAN?: These results can help patients with overactive bladder understand their own chances of treatment success with fesoterodine and can help doctors support their patients on what to expect regarding their specific symptoms and concerns. ▪Toviaz (fesoterodine) is approved to treat the condition that is discussed in this summary. Approval varies from country to country; please check with your local health provider for more details. ▪This summary reports the combined results of 6 studies. The results of individual studies may vary from the combined study results presented here. Individuals should make treatment decisions based on all available evidence. ClinicalTrials.gov NCT number: NCT01302054, NCT01302067, NCT00444925, NCT00611026, NCT00220363, and NCT00138723.

Indexed as

Urinary Bladder, OveractiveBenzhydryl CompoundsHumansLanguageTreatment OutcomeBenzhydryl Compoundsfesoterodineclinical trialfesoterodinelay summaryolder adultoveractive bladderplain language summaryquality of lifetreatment efficacy

Identifiers

PMID35881009
OpenAlexW4288010068

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.