ArticleMicrobiology spectrum2022
Inhibition of Biofilm Formation and Virulence Factors of Cariogenic Oral Pathogen Streptococcus mutans by Shikimic Acid.
Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Effects of D-Tagatose on Cariogenic Risk: A Systematic Review of Randomized Clinical Trials.Nutrients · 2025Pooled it
- Key virulence genes associated withFrontiers in oral health · 2025Pooled it
- In Vitro Antibacterial and Antibiofilm Effects of Antiseptics and Mouthwashes onPathogens (Basel, Switzerland) · 2026Article
- Classification and Anti-Pathogens (Basel, Switzerland) · 2026Review
- Buprenorphine enhancesJournal of oral microbiology · 2026Article
- Inhibition of the Biofilm Formation of PlantPharmaceuticals (Basel, Switzerland) · 2024Review
- Biofilm targeting with chitosan-based nanohydrogel containing Quercus infectoria G. Olivier extract against Streptococcus mutans: new formulations of a traditional natural product.BMC complementary medicine and therapies · 2024Article
- Unleashing nature's defense: potent antimicrobial power of plant extracts against oral pathogens and Streptococcus mutans biofilms.Frontiers in oral health · 2024Article
- Mucoadhesive Pharmacology: Latest Clinical Technology in Antiseptic Gels.Gels (Basel, Switzerland) · 2023Article
- Antimicrobial peptide temporin derivatives inhibit biofilm formation and virulence factor expression ofFrontiers in microbiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus mutans is known as an important oral pathogen causing dental caries, a widespread oral infectious disease. S. mutans synthesize exopolysaccharide (EPS) using glucosyltransferases (Gtfs), resulting in biofilm formation on the tooth surface. Bacterial cells in the biofilms become strongly resistant to a harsh environment, such as antibiotics and host defense mechanisms, making biofilm-based infections difficult to eliminate. Discovering novel antibiofilm agents, especially from natural products, helps to develop effective strategies against this kind of diseases. The present study investigated the inhibitory effect of shikimic acid (SA), one abundant compound derived from
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.