Evidence map›Paper›PMID 35880807›Full record

ArticleDiabetes care2022

Physical Function in Middle-aged and Older Adults With Type 1 Diabetes: Long-term Follow-up of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study.

Catherine L Martin, Victoria R Trapani, Jye-Yu C Backlund, Pearl Lee, Barbara H Braffett, Ionut Bebu, John M Lachin, Alan M Jacobson, Rose Gubitosi-Klug, William H Herman and 1 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Precision Medicine in Type 1 Diabetes.Journal of the Indian Institute of Science · 2023
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Catherine L MartinDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI.
Victoria R TrapaniBiostatistics Center, The George Washington University, Rockville, MD.
Jye-Yu C BacklundBiostatistics Center, The George Washington University, Rockville, MD.
Pearl LeeDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI.ORCID 0000-0002-4678-4168
Barbara H BraffettBiostatistics Center, The George Washington University, Rockville, MD.ORCID 0000-0002-2184-9754
Ionut BebuBiostatistics Center, The George Washington University, Rockville, MD.ORCID 0000-0002-4944-7968
John M LachinBiostatistics Center, The George Washington University, Rockville, MD.ORCID 0000-0001-9838-2841
Alan M JacobsonNYU Long Island School of Medicine, NYU Langone Hospital-Long Island, Mineola.
Rose Gubitosi-KlugCase Western Reserve University, Rainbow Babies and Children's Hospital, Cleveland, OH.ORCID 0000-0002-7376-6870
William H HermanDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI.
DCCT/EDIC Research Group
George Washington University · USUniversity of Michigan · USIsland Hospital · USRainbow Babies & Children's Hospital · US

Funding

Limited Competition for the Continuation of Epidemiology of Diabetes Interventions and Complications (EDIC) Study Clinical Research Center (Collaborative U01)U01DK094157 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Ionut Bebu, Barbara Halina Braffett · 2011 to 2026
$97.6M
Epidemiology of Diabetes Interventions and Complications Data Coordinating CenterU01DK094176 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI BEBU, IONUT, BRAFFETT, BARBARA HALINA · 2012 to 2022
$30.8M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
NIDDK NIH HHS P30 DK020572NIDDK NIH HHS U01 DK094157NIDDK NIH HHS U01 DK094176
6 · The paper itself

Abstract

objectiveTo describe the prevalence and clinical correlates of functional limitations in middle-aged and older adults with long-standing type 1 diabetes. RESEARCH DESIGN AND

methodsFunctional limitations were assessed for 1,094 participants in the Epidemiology of Diabetes Interventions and Complications (EDIC) study, a multicenter, longitudinal, observational follow-up of participants with type 1 diabetes randomly assigned to intensive or conventional diabetes therapy during the Diabetes Control and Complications Trial (DCCT). The primary outcome measure was a score <10 on the Short Physical Performance Battery (SPPB). The secondary outcome, self-reported functional limitation, was assessed by written questionnaire. Logistic regression models were used to assess associations of both outcomes with demographic and clinical factors (glycemic and nonglycemic factors, micro- and macrovascular complications, DCCT cohort, and treatment assignment).

resultsParticipants were 53% male, with mean ± SD age 59.5 ± 6.8 years and diabetes duration 37.9 ± 4.9 years. The prevalence of SPPB score <10 was 21%. The prevalence of self-reported functional limitations was 48%. While DCCT treatment assignment was not associated with physical function outcomes measured ∼25 years after the end of the DCCT, the time-weighted mean DCCT/EDIC HbA1c was associated with both outcomes. Other clinical factors associated with both outcomes in multivariable analyses were BMI, general psychological distress, and cardiac autonomic neuropathy.

conclusionsAlmost half of the middle-aged and older adults with long-standing type 1 diabetes reported functional limitations, which were associated with higher HbA1c and BMI, general psychological distress, and cardiac autonomic neuropathy. Future research is needed to determine whether these findings are generalizable.

Indexed as

Diabetes ComplicationsDiabetes Mellitus, Type 1AgedBlood GlucoseFemaleFollow-Up StudiesGlycated HemoglobinHumansMaleMiddle AgedRisk FactorsBlood GlucoseGlycated Hemoglobin

Identifiers

PMID35880807
PMCPMC9472495
OpenAlexW4288037966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.