Evidence map›Paper›PMID 35880535›Full record

ArticleChemical communications (Cambridge, England)2022

Harnessing the intrinsic photochemistry of isoxazoles for the development of chemoproteomic crosslinking methods.

Marshall G Lougee, Vinayak Vishnu Pagar, Hee Jong Kim, Samantha X Pancoe, W Kit Chia, Robert H Mach, Benjamin A Garcia, E James Petersson

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. A Singlet Oxygen-Mediated Route to O,O-Bidentate BFChemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marshall G LougeeDepartment of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA. ejpetersson@sas.upenn.edu.ORCID http://orcid.org/0000-0002-4351-9908
Vinayak Vishnu PagarDepartment of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA. ejpetersson@sas.upenn.edu.ORCID http://orcid.org/0000-0002-6729-693X
Hee Jong KimBiochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID http://orcid.org/0000-0002-0823-5301
Samantha X PancoeDepartment of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA. ejpetersson@sas.upenn.edu.
W Kit ChiaDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA.ORCID http://orcid.org/0000-0002-2901-2035
Robert H MachDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA.ORCID http://orcid.org/0000-0002-7645-2869
Benjamin A GarciaBiochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID http://orcid.org/0000-0003-3596-4750
E James PeterssonDepartment of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA. ejpetersson@sas.upenn.edu.ORCID http://orcid.org/0000-0003-3854-9210

Funding

Medicinal Chemistry CoreU19NS110456 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI ROBERT H MACH · 2019 to 2026
$44.1M
Shared Resources Core 2: Quantitative Proteomics CoreP01CA196539 · NCI · ROCKEFELLER UNIVERSITY · PI YOUNG, MICHAEL WARREN · 2015 to 2024
$17.6M
Training in Alzheimer’s and Age-Related Neurodegenerative DiseasesT32AG000255 · NIA · UNIVERSITY OF PENNSYLVANIA · PI ALICE S CHEN-PLOTKIN, VIRGINIA M LEE · 1997 to 2026
$12.5M
Viral modulation of epitranscriptomic mechanismsR01AI118891 · NIAID · WASHINGTON UNIVERSITY · PI GARCIA, BENJAMIN A, WEITZMAN, MATTHEW D. · 2015 to 2025
$5.4M
Studying Aggregation in Neurodegenerative Disease Using Synthetic ProteinsR01NS103873 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Ernest James Petersson · 2019 to 2026
$2.1M
Time-Of-Flight Instrument with Variable Ionization SourcesS10RR023444 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI DMOCHOWSKI, IVAN JULIAN · 2007 to 2007
$308k
Reconstitution and structural dissection of transcription-coupled histone H3.3 depositionF31AG069390 · NIA · UNIVERSITY OF PENNSYLVANIA · PI KIM, HEE JONG · 2020 to 2022
$126k
NCI NIH HHS P01 CA196539NCRR NIH HHS S10 RR023444NIAID NIH HHS R01 AI118891NIA NIH HHS F31 AG069390NIA NIH HHS T32 AG000255NINDS NIH HHS R01 NS103873NINDS NIH HHS U19 NS110456
6 · The paper itself

Abstract

The intrinsic photochemistry of the isoxazole, a common heterocycle in medicinal chemistry, can be applied to offer an alternative to existing strategies using more perturbing, extrinsic photo-crosslinkers. The utility of isoxazole photo-crosslinking is demonstrated in a wide range of biologically relevant experiments, including common proteomics workflows.

Indexed as

Chemistry, PharmaceuticalIsoxazolesPhotochemistryIsoxazoles

Identifiers

PMID35880535
PMCPMC9922157

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.