Evidence map›Paper›PMID 35880398›Full record

ArticleeLife2022

Population-based sequencing of

Irving Cancino-Muñoz, Mariana G López, Manuela Torres-Puente, Luis M Villamayor, Rafael Borrás, María Borrás-Máñez, Montserrat Bosque, Juan J Camarena, Caroline Colijn, Ester Colomer-Roig and 24 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Use of reverse dot blot hybridization DNA-array and targeted next-generation sequencing for the detection of drug resistance in patients with tuberculosis: a prospective diagnostic accuracy study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  3. Article
  4. Spatio-temporal patterns of tuberculosis revealed by routineThe Lancet regional health. Western Pacific · 2026
    Article
  5. Article
  6. First insights into the genetic composition ofJournal of clinical tuberculosis and other mycobacterial diseases · 2025
    Article
  7. UShER-TB: Scalable, Comprehensive, Accessible Phylogenomic Analysis ofmedRxiv : the preprint server for health sciences · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Melioidosis and Activation from Latency: The "Time Bomb" Has Not Occurred.The American journal of tropical medicine and hygiene · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Gene evolutionary trajectories inProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 17 institutions in 2 countries.

Irving Cancino-Muñoz *Tuberculosis Genomics Unit, Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain.
Mariana G López *Tuberculosis Genomics Unit, Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain.ORCID 0000-0002-2216-9232
Manuela Torres-PuenteTuberculosis Genomics Unit, Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain.ORCID 0000-0002-8352-180X
Luis M VillamayorUnidad Mixta "Infección y Salud Pública" (FISABIO-CSISP), Valencia, Spain.
Rafael BorrásMicrobiology Service, Hospital Clínico Universitario, Valencia, Spain.ORCID 0000-0001-5743-9768
María Borrás-MáñezMicrobiology and Parasitology Service, Hospital Universitario de La Ribera, Alzira, Spain.
Montserrat BosqueMicrobiology Service, Hospital Arnau de Vilanova, Valencia, Spain.
Juan J CamarenaMicrobiology Service, Hospital Universitario Dr Peset, Valencia, Spain.
Caroline ColijnDepartment of Mathematics, Faculty of Science, Simon Fraser University, Burnaby, Canada.ORCID 0000-0001-6097-6708
Ester Colomer-RoigUnidad Mixta "Infección y Salud Pública" (FISABIO-CSISP), Valencia, Spain.
Javier ColominaMicrobiology Service, Hospital Clínico Universitario, Valencia, Spain.
Isabel EscribanoMicrobiology Laboratory, Hospital Virgen de los Lirios, Alcoy, Spain.
Oscar Esparcia-RodríguezMicrobiology Service, Hospital de Denia, Denia, Spain.
Francisco García-GarcíaComputational Genomics Department, Centro de Investigación Príncipe Felipe, Valencia, Spain.
Ana Gil-BrusolaMicrobiology Service, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
Concepción GimenoMicrobiology Service, Hospital General Universitario de Valencia, Valencia, Spain.
Adelina Gimeno-GascónMicrobiology Service, Hospital General Universitario de Alicante, Alicante, Spain.ORCID 0000-0003-3728-3182
Bárbara Gomila-SardMicrobiology Service, Hospital General Universitario de Castellón, Castellón, Spain.
Damiana Gónzales-GrandaMicrobiology Service, Hospital Lluís Alcanyis, Xativa, Spain.
Nieves Gonzalo-JiménezMicrobiology Service, Hospital General Universitario de Elche, Elche, Spain.
María Remedios Guna-SerranoMicrobiology Service, Hospital General Universitario de Valencia, Valencia, Spain.
José Luis López-HontangasMicrobiology Service, Hospital Universitari i Politècnic La Fe, Valencia, Spain.ORCID 0000-0003-1426-3672
Coral Martín-GonzálezMicrobiology Service, Hospital Universitario de San Juan de Alicante, Alicantes, Spain.
Rosario Moreno-MuñozMicrobiology Service, Hospital General Universitario de Castellón, Castellón, Spain.ORCID 0000-0002-0185-5612
David NavarroMicrobiology Service, Hospital Clínico Universitario, Valencia, Spain.
María NavarroMicrobiology Service, Hospital de la Vega Baixa, Orihuela, Spain.
Nieves OrtaMicrobiology Service, Hospital Universitario de San Juan de Alicante, Alicantes, Spain.
Elvira PérezSubdirección General de Epidemiología y Vigilancia de la Salud y Sanidad Ambiental de Valencia (DGSP), Valencia, Spain.
Josep PratMicrobiology Service, Hospital de Sagunto, Sagunto, Spain.
Juan Carlos RodríguezMicrobiology Service, Hospital General Universitario de Alicante, Alicante, Spain.
Ma Montserrat Ruiz-GarcíaMicrobiology Service, Hospital General Universitario de Elche, Elche, Spain.
Hermelinda VanaclochaSubdirección General de Epidemiología y Vigilancia de la Salud y Sanidad Ambiental de Valencia (DGSP), Valencia, Spain.ORCID 0000-0002-5655-5924
Valencia Region Tuberculosis Working Group
Iñaki ComasTuberculosis Genomics Unit, Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain.ORCID 0000-0001-5504-9408
Instituto de Biomedicina de Valencia · ESFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana · ESHospital General Universitari de Castelló · ESHospital General Universitario de Alicante Doctor Balmis · ESHospital General Universitario de Elche · ESHospital General Universitario De Valencia · ESHospital Universitari i Politècnic La Fe · ESHospital Universitari Sant Joan D'Alacant · ESCentro de Investigacion Principe Felipe · ESHospital Arnau de Vilanova · ESHospital de La Ribera · ESHospital de Sagunto · ESHospital Universitario Doctor Peset · ESHospital Universitario Lluís Alcanyís · ESHospital Vega Baja · ESHospital Virgen de los Lirios · ESSimon Fraser University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transmission is a driver of tuberculosis (TB) epidemics in high-burden regions, with assumed negligible impact in low-burden areas. However, we still lack a full characterization of transmission dynamics in settings with similar and different burdens. Genomic epidemiology can greatly help to quantify transmission, but the lack of whole genome sequencing population-based studies has hampered its application. Here, we generate a population-based dataset from Valencia region and compare it with available datasets from different TB-burden settings to reveal transmission dynamics heterogeneity and its public health implications. We sequenced the whole genome of 785

Indexed as

EpidemicsMycobacterium tuberculosisTuberculosisHumansPopulation DynamicsWhole Genome Sequencingepidemiologygenomic epidemiologyglobal healthMycobacterium tuberculosistransmissiontuberculosiswhole-genome sequencing

Identifiers

PMID35880398
PMCPMC9323001
OpenAlexW4287831560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.