Evidence map›Paper›PMID 35880377›Full record

ArticleJournal of movement disorders2022

Sensitivity of Detecting Alpha-Synuclein Accumulation in the Gastrointestinal Tract and Tissue Volume Examined.

Chaewon Shin, Seong-Ik Kim, Sung-Hye Park, Jung Hwan Shin, Chan Young Lee, Han-Kwang Yang, Hyuk-Joon Lee, Seong-Ho Kong, Yun-Suhk Suh, Han-Joon Kim and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of movement disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Chaewon ShinDepartment of Neurology, Chungnam National University Sejong Hospital, Chungnam National University College of Medicine, Sejong, Korea.
Seong-Ik KimDepartment of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Sung-Hye ParkDepartment of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Jung Hwan ShinDepartment of Neurology, MRC and Movement Disorder Center, Seoul National University Hospital, Parkinson Study Group, Seoul National University College of Medicine, Seoul, Korea.
Chan Young LeeDepartment of Neurology, Ehwa Womans University Mokdong Hospital, Seoul, Korea.
Han-Kwang YangDepartment of Surgery, Cancer Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Hyuk-Joon LeeDepartment of Surgery, Cancer Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Seong-Ho KongDepartment of Surgery, Cancer Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Yun-Suhk SuhDepartment of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.
Han-Joon KimDepartment of Neurology, MRC and Movement Disorder Center, Seoul National University Hospital, Parkinson Study Group, Seoul National University College of Medicine, Seoul, Korea.
Beomseok JeonDepartment of Neurology, MRC and Movement Disorder Center, Seoul National University Hospital, Parkinson Study Group, Seoul National University College of Medicine, Seoul, Korea.
Seoul National University Hospital · KRSeoul National University · KRChungnam National University · KREwha Womans University · KRSeoul National University Bundang Hospital · KR

Funding

Chungnam National University Sejong Hospital 2021-S4-003National Research Foundation of Korea 2018R1D1A1B07041440Seoul National University Hospital 0420170460
6 · The paper itself

Abstract

objectiveThis study aimed to evaluate whether a larger tissue volume increases the sensitivity of detecting alpha-synuclein (AS) pathology in the gastrointestinal (GI) tract.

methodsNine patients with Parkinson's disease (PD) or idiopathic rapid eye movement sleep disorder (iRBD) who underwent GI operation and had full-depth intestinal blocks were included. All patients were selected from our previous study population. A total of 10 slides (5 serial sections from the proximal and distal blocks) per patient were analyzed.

resultsIn previous studies, pathologic evaluation revealed phosphorylated AS (+) in 5/9 patients (55.6%) and in 1/5 controls (20.0%); in this extensive examination, this increased to 8/9 patients (88.9%) but remained the same in controls (20.0%). The severity and distribution of positive findings were similar between patients with iRBD and PD.

conclusionExamining a large tissue volume increased the sensitivity of detecting AS accumulation in the GI tract.

Indexed as

Alpha-synucleinGastrointestinal tractImmunohistochemistrySynucleinopathyVolume

Identifiers

PMID35880377
PMCPMC9536904
OpenAlexW4287831851

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.