Evidence map›Paper›PMID 35880242›Full record

ReviewRheumatology and immunology research2021

Cardiovascular disease in systemic lupus erythematosus.

Maureen McMahon, Richard Seto, Brian J Skaggs

Open access · diamondAbstract readReview
In one paragraph

Review in Rheumatology and immunology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Acute Coronary Syndrome and Rheumatic Disease.Journal of clinical medicine · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Biologics : targets & therapy · 2024
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Maureen McMahonUCLA David Geffen School of Medicine, Division of Rheumatology, 32-59 Rehab Center, 1000 Veteran Avenue, Los Angeles, CA 90095, USA.
Richard SetoUCLA David Geffen School of Medicine, Division of Rheumatology, 32-59 Rehab Center, 1000 Veteran Avenue, Los Angeles, CA 90095, USA.
Brian J SkaggsUCLA David Geffen School of Medicine, Division of Rheumatology, 32-59 Rehab Center, 1000 Veteran Avenue, Los Angeles, CA 90095, USA.
University of California, Los Angeles · US

Funding

The PREDICTS risk score for increased atherosclerosis and disease activity in SLER01AR063754 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCMAHON, MAUREEN A · 2014 to 2018
$2.8M
NIAMS NIH HHS R01 AR063754
6 · The paper itself

Abstract

There is a well-known increased risk for cardiovascular disease that contributes to morbidity and mortality in systemic lupus erythematosus (SLE). Major adverse cardiovascular events and subclinical atherosclerosis are both increased in this patient population. While traditional cardiac risk factors do contribute to the increased risk that is seen, lupus disease-related factors, medications, and genetic factors also impact the overall risk. SLE-specific inflammation, including oxidized lipids, cytokines, and altered immune cell subtypes all are likely to play a role in the pathogenesis of atherosclerotic plaques. Research is ongoing to identify biomarkers that can help clinicians to predict which SLE patients are at the greatest risk for cardiovascular disease (CVD). While SLE-specific treatment regimens for the prevention of cardiovascular events have not been identified, current strategies include minimization of traditional cardiac risk factors and lowering of overall lupus disease activity.

Indexed as

atherosclerosisbiomarkerscardiovascular diseasemyocardial infarctionpreventionstroke

Identifiers

PMID35880242
PMCPMC9242526
OpenAlexW4205548674

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.