Evidence map›Paper›PMID 35880207›Full record

ArticleAmerican journal of ophthalmology case reports2022

Reflectance adaptive optics findings in a patient with Vogt-Koyanagi-Harada disease.

Aarin Thuan Pham, Neil Onghanseng, Muhammad Sohail Halim, Maria Soledad Ormaechea, Muhammad Hassan, Amir Akhavanrezayat, Gunay Uludag, Anh Nt Tran, Moataz M Razeen, Nripun Sredar and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Aarin Thuan PhamByers Eye Institute, Stanford University, Palo Alto, CA, USA.
Neil OnghansengByers Eye Institute, Stanford University, Palo Alto, CA, USA.
Muhammad Sohail HalimByers Eye Institute, Stanford University, Palo Alto, CA, USA.
Maria Soledad OrmaecheaByers Eye Institute, Stanford University, Palo Alto, CA, USA.
Muhammad HassanByers Eye Institute, Stanford University, Palo Alto, CA, USA.
Amir AkhavanrezayatByers Eye Institute, Stanford University, Palo Alto, CA, USA.
Gunay UludagByers Eye Institute, Stanford University, Palo Alto, CA, USA.
Anh Nt TranByers Eye Institute, Stanford University, Palo Alto, CA, USA.
Moataz M RazeenByers Eye Institute, Stanford University, Palo Alto, CA, USA.
Nripun SredarByers Eye Institute, Stanford University, Palo Alto, CA, USA.
Alfredo DubraByers Eye Institute, Stanford University, Palo Alto, CA, USA.
Quan Dong NguyenByers Eye Institute, Stanford University, Palo Alto, CA, USA.
Smith-Kettlewell Eye Research Institute · USHospital Universitario Austral · AR

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
NEI NIH HHS P30 EY026877
6 · The paper itself

Abstract

Purpose: To describe the reflectance adaptive optics scanning laser ophthalmoscopy (AOSLO) findings in different stages of Vogt-Koyanagi-Harada (VKH) disease and correlate them to visual gain post treatment. Confocal (cAOSLO) and non-confocal split-detector AOSLO (sdAOSLO) were used to assess longitudinally the status of the photoreceptors in a patient with VKH managed on corticosteroid and immunomodulatory therapy. Observation: A 32-year-old Japanese American female presented with a 2-week history of blurred vision in both eyes (OU) and worsening headache previously diagnosed as a case of VKH and treated with high dose oral prednisone. At the time of presentation, though vision was improving, and frank serous retinal detachments were absent, spectral domain optical coherence tomography (SD-OCT) showed presence of residual subretinal fluid with disruption of the photoreceptor inner segments and outer segments (IS/OS) involving OU. The photoreceptor mosaic at the foveal center appeared very sparse with large areas devoid of visible photoreceptors on cAOSLO, in agreement with the SD-OCT data. sdAOSLO imaging over the same location shows a higher number of contiguous photoreceptors. After imaging, the patient was started on mycophenolate mofetil as steroid-sparing long-term therapy. Three months later, visual acuity improved to 20/20 OU, and SD-OCT showed almost complete resolution of subretinal fluid with significant improvement of the IS/OS SD-OCT signal, OU. cAOSLO imaging revealed a contiguous photoreceptor mosaic without gaps and of normal appearance. Conclusions and Importance: VKH patients may demonstrate transient photoreceptor abnormalities on SD-OCT and cAOSLO imaging. sdAOSLO imaging revealed intact photoreceptor segments in areas that appeared as voids on cAOSLO, which later showed structural recovery on SD-OCT and cAOSLO. Therefore, sdAOSLO may predict potential for improvement in patients wherein there appears to be photoreceptor loss in cAOSLO and/or SD-OCT.

Indexed as

Adaptive opticsAOSLOCone photoreceptorsSplit-detectionVKHVogt-koyanagi-harada

Identifiers

PMID35880207
PMCPMC9307596
OpenAlexW4285404578

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.