Evidence map›Paper›PMID 35880064›Full record

ArticleClinical kidney journal2022

Dynamics of SARS-CoV-2-Spike-reactive antibody and T-cell responses in chronic kidney disease patients within 3 months after COVID-19 full vaccination.

Nayara Panizo, Eliseo Albert, Elena Giménez-Civera, Maria Jesús Puchades, Luis D'Marco, Lorena Gandía-Salmerón, Estela Giménez, Ignacio Torre, Asunción Sancho, Eva Gavela and 10 more

Open access · goldAbstract read
In one paragraph

Article in Clinical kidney journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Nayara PanizoNephrology Service, Hospital Clínico Universitario de Valencia, INCLIVA Health Research Institutue, Valencia, Spain.ORCID https://orcid.org/0000-0002-1329-2976
Eliseo AlbertMicrobiology Service, Hospital Clínico Universitario de Valencia, INCLIVA Health Research Institute, Valencia, Spain.
Elena Giménez-CiveraNephrology Service, Hospital Clínico Universitario de Valencia, INCLIVA Health Research Institutue, Valencia, Spain.
Maria Jesús PuchadesNephrology Service, Hospital Clínico Universitario de Valencia, INCLIVA Health Research Institutue, Valencia, Spain.
Luis D'MarcoUniversidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain.ORCID https://orcid.org/0000-0003-0148-891X
Lorena Gandía-SalmerónNephrology Service, Hospital Clínico Universitario de Valencia, INCLIVA Health Research Institutue, Valencia, Spain.
Estela GiménezMicrobiology Service, Hospital Clínico Universitario de Valencia, INCLIVA Health Research Institute, Valencia, Spain.
Ignacio TorreMicrobiology Service, Hospital Clínico Universitario de Valencia, INCLIVA Health Research Institute, Valencia, Spain.
Asunción SanchoNephrology Service, Transplant Unit, Hospital Universitario Dr. Peset, Valencia, Spain.ORCID https://orcid.org/0000-0002-4170-9003
Eva GavelaNephrology Service, Transplant Unit, Hospital Universitario Dr. Peset, Valencia, Spain.
Miguel Gonzalez-RicoNephrology Service, Hospital Clínico Universitario de Valencia, INCLIVA Health Research Institutue, Valencia, Spain.
Marco MontomoliNephrology Service, Hospital Clínico Universitario de Valencia, INCLIVA Health Research Institutue, Valencia, Spain.
Carmen Maria Perez-BaylachB BraumAvitum Hemodialysis Centres Valnefron Valencia and Massamagrell, Valencia, Spain.
Begoña BonillaB BraumAvitum Hemodialysis Centres Valnefron Valencia and Massamagrell, Valencia, Spain.
Camila SolanoNephrology Service, Hospital Clínico Universitario de Valencia, INCLIVA Health Research Institutue, Valencia, Spain.
Mª Fernanda AlvaradoNephrology Service, Hospital Clínico Universitario de Valencia, INCLIVA Health Research Institutue, Valencia, Spain.
Isidro TorregrosaNephrology Service, Hospital Clínico Universitario de Valencia, INCLIVA Health Research Institutue, Valencia, Spain.
María Jesús AlcarazMicrobiology Service, Hospital Clínico Universitario de Valencia, INCLIVA Health Research Institute, Valencia, Spain.
José Luis GórrizNephrology Service, Hospital Clínico Universitario de Valencia, INCLIVA Health Research Institutue, Valencia, Spain.ORCID https://orcid.org/0000-0002-1134-9051
David NavarroMicrobiology Service, Hospital Clínico Universitario de Valencia, INCLIVA Health Research Institute, Valencia, Spain.
Hospital Clínico Universitario de Valencia · ESHospital Universitario Doctor Peset · ESUniversitat de València · ESUniversidad Cardenal Herrera CEU · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Little is known regarding the dynamics of antibody and T-cell responses in chronic kidney disease (CKD) following coronavirus disease 2019 (COVID-19) vaccination. Methods: Prospective observational cohort study including 144 participants on haemodialysis (HD) ( Results: Anti-S antibodies at 15D and 3M were detectable in 95% (48/50)/98% (49/50) of HD patients, 93% (13/14)/100% of PD patients, 67% (17/26)/75% (21/28) of KT patients and 96% (25/26)/100% (24/24) of ACKD patients. Rates for healthy controls were 81% (13/16)/100% (17/17). Previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2-S) infection was documented in four (7.7%) HD patients, two (14.3%) PD patients, two (6.7%) KT patients, one (5.55%) healthy control and in no ACKD patient. Antibody levels decreased at 3M in HD ( Conclusions: Most HD, PD and ACKD patients develop SARS-CoV-2-S antibody responses comparable to that of healthy controls, in contrast to KT recipients. Antibody waning at 3M was faster in HD, PD and ACKD patients. No differences in SARS-CoV-2 T-cell immunity responses were noticed across study groups.

Indexed as

chronic kidney diseasedialysiskidney transplantationSARS-CoV-2-S antibodiesSARS-CoV-2-S T-cells

Identifiers

PMID35880064
PMCPMC9047236
OpenAlexW4225847478

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.