Evidence map›Paper›PMID 35879974›Full record

ArticleJournal of hepatocellular carcinoma2022

Natural Killer Group 2D Receptor and B1a Cells Crosstalk in Post-Hepatitis C Virus Infection Hepatocellular Carcinoma and Cirrhosis.

Reham Hammad, Mona A Eldosoky, Alshaimaa M Mosaad, Asmaa M El-Nasser, Fatma M Kotb, Salwa I Elshennawy, Noha Abdel-Rahman Eldesoky, Mohamed A Selim, Gina G Naguib, Ossama A Ahmed and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of hepatocellular carcinoma, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Reham HammadClinical Pathology Department, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.ORCID 0000-0002-8967-9106
Mona A EldosokyClinical Pathology Department, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.
Alshaimaa M MosaadHepatogastroenterology and Infectious Diseases Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Asmaa M El-NasserMedical Microbiology and Immunology Department, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.
Fatma M KotbInternal Medicine Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.ORCID 0000-0001-8882-2516
Salwa I ElshennawyClinical Pathology Department, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.
Noha Abdel-Rahman EldesokyBiochemistry and Molecular Biology Department, Faculty of Pharmacy (for Girls), Al-Azhar University, Cairo, Egypt.
Mohamed A SelimBotany and Microbiology Department, Faculty of Science (for Boys), Al-Azhar University, Cairo, Egypt.
Gina G NaguibInternal Medicine, Gastroenterology and Hepatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.ORCID 0000-0001-9336-4329
Ossama A AhmedInternal Medicine, Gastroenterology and Hepatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mohamed AlboraieDepartment of internal medicine, Al-Azhar University, Cairo, Egypt.ORCID 0000-0002-8490-9822
Reda Badr AglanHepatology and Gastroenterology Department, National Liver Institute Menoufia university, Menoufia, Egypt.ORCID 0000-0001-6900-039X
Al-Azhar University · EGAin Shams University · EGMenoufia University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Natural killer (NK) and B1a cells are implicated in innate immune surveillance against chronic hepatitis C virus (CHCV). NK group 2D (NKG2D) receptor is important for B cell differentiation. This study was designed to assess whether B1a cells and NK Cells expressing NKG2D are implicated in post-hepatitis C infection hepatocellular carcinoma (post-HCV HCC) and cirrhosis using flow cytometry and investigate the association between NK-expressing NKG2D and B1a in complications of CHCV infection. Methods: In this cross-sectional study, 111 participants were included and divided into the post-HCV HCC (n = 50), post-HCV liver cirrhosis (n = 31), and CHCV (n = 30) groups. Results: The percentage of B1a cells (B1a%) and the mean fluorescence intensity (MFI) of NKG2D (NKG2D MFI) showed a significant increase in the CHCV group compared with those in the post-HCV liver cirrhosis and post-HCV HCC groups ( Conclusion: Downregulation of B1a frequency and NKG2D intensity is implicated in the progression of CHCV infection to cirrhosis and HCC. NKG2D receptor is associated with the frequency of circulating B1a cells. NKG2D intensity and B1a% can be used as indicators of CHCV progression.

Indexed as

B1a cellschronic hepatitis Chepatocellular carcinomaNKG2D

Identifiers

PMID35879974
PMCPMC9307915
OpenAlexW4285735861

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.