Evidence map›Paper›PMID 35879771›Full record

ArticleGenome biology2022

Development of a highly efficient prime editor 2 system in plants.

Juan Li, Like Chen, Jing Liang, Rongfang Xu, Yingli Jiang, Yizhen Li, Jian Ding, Min Li, Ruiying Qin, Pengcheng Wei

Abstract read
In one paragraph

Article in Genome biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Juan LiKey Laboratory of Rice Genetic Breeding of Anhui Province, Rice Research Institute, Anhui Academy of Agricultural Sciences, Hefei, 230031, P.R. China.
Like ChenCollege of Agronomy, Anhui Agricultural University, Hefei, 230036, P.R. China.
Jing LiangCollege of Agronomy, Anhui Agricultural University, Hefei, 230036, P.R. China.
Rongfang XuKey Laboratory of Rice Genetic Breeding of Anhui Province, Rice Research Institute, Anhui Academy of Agricultural Sciences, Hefei, 230031, P.R. China.
Yingli JiangCollege of Agronomy, Anhui Agricultural University, Hefei, 230036, P.R. China.
Yizhen LiCollege of Agronomy, Anhui Agricultural University, Hefei, 230036, P.R. China.
Jian DingCollege of Agronomy, Anhui Agricultural University, Hefei, 230036, P.R. China.
Min LiCollege of Agronomy, Anhui Agricultural University, Hefei, 230036, P.R. China.
Ruiying QinKey Laboratory of Rice Genetic Breeding of Anhui Province, Rice Research Institute, Anhui Academy of Agricultural Sciences, Hefei, 230031, P.R. China.
Pengcheng WeiKey Laboratory of Rice Genetic Breeding of Anhui Province, Rice Research Institute, Anhui Academy of Agricultural Sciences, Hefei, 230031, P.R. China. weipengcheng@gmail.com.ORCID 0000-0001-5403-9451

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low efficiency has seriously restricted the application of prime editing (PE) systems in plants. In this study, we develop an enhanced plant prime editor 2 system, enpPE2, by stacking various optimization strategies, including updating the PE architecture to PEmax and expressing engineered pegRNA with a structured motif under the control of a composite promoter. In T

Indexed as

Gene EditingOryzaCRISPR-Cas SystemsGenome, PlantPlantsEfficiencyEngineeringPrecise editingPrime editingRice

Identifiers

PMID35879771
PMCPMC9310484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.