Evidence map›Paper›PMID 35879665›Full record

SynthesisBMC geriatrics2022

Effect of multicomponent exercise in cognitive impairment: a systematic review and meta-analysis.

Luis Carlos Venegas-Sanabria, Iván Cavero-Redondo, Vicente Martínez-Vizcaino, Carlos Alberto Cano-Gutierrez, Celia Álvarez-Bueno

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  7. [PAPPS update on older people 2024].Atencion primaria · 2024
    Guideline
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Luis Carlos Venegas-SanabriaUniversidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, Spain.
Iván Cavero-RedondoUniversidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, Spain. ivan.cavero@uclm.es.
Vicente Martínez-VizcainoUniversidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, Spain.
Carlos Alberto Cano-GutierrezAging Institute, Medicine School, Pontificia Universidad Javeriana, Bogotá, Colombia.
Celia Álvarez-BuenoUniversidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMulticomponent physical exercise is the most recommended type of physical intervention in older adults. Experimental data suggest the relevance of the muscle-brain axis and the relationship between muscle contraction and release of brain-derived neurotrophic factor, however, the impact of this relationship on cognition remains unclear, especially in people with diagnosis of cognitive impairment. This study assesses the effect of multicomponent physical exercise on global cognition in people with mild cognitive impairment or dementia.

methodsRandomized controlled trials published until January 2021 were searched across three electronic databases (PubMed, Scopus, and Cochrane Database). Data about exercises included in the multicomponent intervention (endurance, strength, balance, or flexibility), the inclusion of aerobic exercise, and the change in global cognition were extracted. The effect size was represented as a standardized mean difference. Risk of bias was assessed by the RoB2 tool.

resultsA total of 8 studies were included. The overall effect size suggested an effect of multicomponent exercise on global cognition. However, the subgroup analysis showed an effect only when aerobic exercise was included in the intervention. No effect when mild cognitive impairment and dementia were assessed separately was found.

conclusionThis study suggests that multicomponent physical exercise could have an effect on global cognition in people with mild cognitive impairment or dementia only when aerobic exercise is included in the intervention. Our results support the inclusion of structured physical exercise programs in the management of people with cognitive impairment.

Indexed as

Cognitive DysfunctionDementiaAgedCognitionExerciseExercise TherapyHumansCognitive impairmentMeta-analysisNon-pharmacological treatmentPhysical activity

Identifiers

PMID35879665
PMCPMC9316334

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.