ArticleBMC bioinformatics2022
HIMA2: high-dimensional mediation analysis and its application in epigenome-wide DNA methylation data.
Article in BMC bioinformatics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Differential DNA methylation in blood as potential mediator of the association between ambient PMMolecular psychiatry · 2026Article
- Gene set mediation analysis in high-dimensional epigenetic studies.Briefings in bioinformatics · 2026Article
- Sparse CCA-based mediation analysis with high-dimensional exposures and mediators.Bioinformatics (Oxford, England) · 2026Article
- Pathway-level epigenetic modeling illuminates the methylation architecture to asthma risk across tissues.Epigenetics & chromatin · 2026Article
- ESPLSM: An Efficient and Interpretable Mediation Analysis Framework Using Sparse Envelopes.Statistics in medicine · 2026Article
- BHMnet: Bayesian high-dimensional mediation analysis with network information integration for correlated mediators.Briefings in bioinformatics · 2026Article
- Bayesian Variable Selection for High-Dimensional Mediation Analysis: Application to Metabolomics Data in Epidemiological Studies.Statistics in medicine · 2026Article
- Current approaches and advances in placental toxicology.Trends in endocrinology and metabolism: TEM · 2026Review
- Powerful large scale inference in high dimensional mediation analysis.PLoS computational biology · 2026Article
- Epigenetic mediation may explain intergenerational associations between maternal obesogenic lifestyle and children's birth weight: findings from the NorthPop prospective birth cohort.Clinical epigenetics · 2025Article
- HILAMA: High-dimensional multi-omics mediation analysis with latent confounding.BMC medical research methodology · 2025Article
- High-dimensional causal mediation analysis by partial sum statistic and sample splitting strategy in imaging genetics application.Bioinformatics (Oxford, England) · 2025Article
- Transfer learning reveals the mediating mechanisms of cross-ethnic lipid metabolic pathways in the association between APOE gene and Alzheimer's disease.Briefings in bioinformatics · 2025Article
- Placental DNA methylation key topics: sex- and cell-type specificity, mediation, multi-omics, and biomarker discovery.Epigenomics · 2025Review
- Time-varying mediation analysis for incomplete data with application to DNA methylation study for PTSD.bioRxiv : the preprint server for biology · 2025Article
- CRAmed: a conditional randomization test for high-dimensional mediation analysis in sparse microbiome data.Bioinformatics (Oxford, England) · 2025Article
- A Bayesian high-dimensional mediation analysis for multilevel genome-wide epigenetic data.Journal of applied statistics · 2025Article
- A novel strategy for detecting multiple mediators in high-dimensional mediation models.Frontiers in psychiatry · 2025Article
- Oculomics meets exposomics: a roadmap for applying multi-modal ocular biomarkers in precision environmental health research.Exposome · 2025Review
- Epigenome-wide mediation analysis of the relationship between psychosocial stress and cardiometabolic risk factors in the Health and Retirement Study (HRS).Clinical epigenetics · 2024Article
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8 authors.
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Abstract
Mediation analysis plays a major role in identifying significant mediators in the pathway between environmental exposures and health outcomes. With advanced data collection technology for large-scale studies, there has been growing research interest in developing methodology for high-dimensional mediation analysis. In this paper we present HIMA2, an extension of the HIMA method (Zhang in Bioinformatics 32:3150-3154, 2016). First, the proposed HIMA2 reduces the dimension of mediators to a manageable level based on the sure independence screening (SIS) method (Fan in J R Stat Soc Ser B 70:849-911, 2008). Second, a de-biased Lasso procedure is implemented for estimating regression parameters. Third, we use a multiple-testing procedure to accurately control the false discovery rate (FDR) when testing high-dimensional mediation hypotheses. We demonstrate its practical performance using Monte Carlo simulation studies and apply our method to identify DNA methylation markers which mediate the pathway from smoking to reduced lung function in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.
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