ArticleScientific reports2022
Altered resting-state functional connectivity within corticostriatal and subcortical-striatal circuits in chronic pain.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Structural and Functional Neuroimaging Findings in Fibromyalgia: A Systematic Review.European journal of pain (London, England) · 2026Pooled it
- Connectomic Mapping of Chronic Musculoskeletal Pain: Neural Circuitries Identified Through a Systematic Review and ALE Meta-Analysis.Neural plasticity · 2026Pooled it
- Contemporary evidence for central nervous system mechanisms underlying chronic pain perception, modulation, and chronification in adults: a scoping review.Frontiers in pain research (Lausanne, Switzerland) · 2026Pooled it
- Seed-based resting-state connectivity as a neurosignature in fibromyalgia and depression: a narrative systematic review.Frontiers in human neuroscience · 2025Pooled it
- Brain stimulation targets for chronic pain: Insights from meta-analysis, functional connectivity and literature review.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Pooled it
- Telehealth-delivered cognitive behavioral therapy - a potential solution to improve sleep quality and normalize the salience network in fibromyalgia: a pilot randomized trial.Brain imaging and behavior · 2024Trial
- Pain hypervigilance is associated with daily-activity pain beyond resting pain in women with fibromyalgia: a cross-sectional observational study.Clinical rheumatology · 2026Observational
- Resting state brain connectivity of pain and fatigue is affected by performance of a fatiguing attention task in patients with chronic pain.Neuroimage. Reports · 2026Article
- Effects of electroacupuncture at Zusanli on pain-perception-related brain nuclei in KOA mice: a study on cortical and subcortical c-fos expression.Behavioral and brain functions : BBF · 2026Article
- Decoding chronic pain: integrating genetics, neuroimaging, and AI for precision management.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Precision connectivity in osteoarthritis pain with permutation and network analysis: a key step toward clinical application.BMC medical imaging · 2025Article
- Precision Connectivity in Arthritis Pain with Permutation and Network Analysis: A Key Step Toward Clinical Application.Research square · 2025Article
- Neural correlates of altered reward-driven attention in chronic pain and opioid use.Scientific reports · 2025Article
- Peak alpha frequency is related to the degree of widespread pain, but not pain intensity or duration, among people with urologic chronic pelvic pain syndrome.Pain reports · 2025Article
- Joint Pain and Leisure-Time Physical Activity: Cross-Sectional Findings From the Cardiovascular Health Study.Health science reports · 2025Article
- Decoding chronic pain: the glutamate-GABA tug of war in the cerebral cortex.Frontiers in molecular neuroscience · 2025Review
- Socioeconomic Status, Trauma, Cognitive Function, Impulsivity, Reward Salience, and Future Substance Use: Role of Left Caudate Connectivity with the Cingulo-Opercular Network.Journal of cellular neuroscience · 2025Article
- Integrating nociplastic pain into neuropathic pain framework: a proposal for a revised classification.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Central effects of short-term spinal cord stimulation in postherpetic neuralgia: a longitudinal fMRI and DTI study.Frontiers in neuroscience · 2025Article
- Neuroimaging of opioid effects in humans across conditions of acute administration, chronic pain therapy, and opioid use disorder.Trends in neurosciences · 2024Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Brain corticostriatal circuits are important for understanding chronic pain and highly relevant to motivation and cognitive processes. It has been demonstrated that in patients with chronic back pain, altered nucleus accumbens (NAcc)-medial prefrontal cortex (MPFC) circuit fMRI-based activity is predictive of patient outcome. We evaluated the NAcc-MPFC circuit in patients with another chronic pain condition, fibromyalgia, to extend these important findings. First, we compared fMRI-based NAcc-MPFC resting-state functional connectivity in patients with fibromyalgia (N = 32) vs. healthy controls (N = 37). Compared to controls, the NAcc-MPFC circuit's connectivity was significantly reduced in fibromyalgia. In addition, within the fibromyalgia group, NAcc-MPFC connectivity was significantly correlated with trait anxiety. Our expanded connectivity analysis of the NAcc to subcortical brain regions showed reduced connectivity of the right NAcc with mesolimbic circuit regions (putamen, thalamus, and ventral pallidum) in fibromyalgia. Lastly, in an exploratory analysis comparing our fibromyalgia and healthy control cohorts to a separate publicly available dataset from patients with chronic back pain, we identified reduced NAcc-MPFC connectivity across both the patient groups with unique alterations in NAcc-mesolimbic connectivity. Together, expanding upon prior observed alterations in brain corticostriatal circuits, our results provide novel evidence of altered corticostriatal and mesolimbic circuits in chronic pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.