Evidence map›Paper›PMID 35879562›Full record

ArticleJournal of neurology2022

Plasma biomarkers inclusive of α-synuclein/amyloid-beta40 ratio strongly correlate with Mini-Mental State Examination score in Parkinson's disease and predict cognitive impairment.

Daniel Kam Yin Chan, Jack Chen, Ren Fen Chen, Jayesh Parikh, Ying Hua Xu, Peter A Silburn, George D Mellick

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Daniel Kam Yin ChanUniversity of New South Wales, Sydney, Australia. d.chan@unsw.edu.au.ORCID http://orcid.org/0000-0003-0481-3933
Jack ChenUniversity of New South Wales, Sydney, Australia.
Ren Fen ChenCentral Sydney Immunology Laboratory at Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Jayesh ParikhBankstown-Lidcombe Hospital, Eldridge Rd,, Bankstown, NSW, 2200, Australia.
Ying Hua XuUniversity of New South Wales, Sydney, Australia.
Peter A SilburnQueensland Brain Institute, University of Queensland, Brisbane, QLD, Australia.
George D MellickGriffith University, Brisbane, QLD, Australia.
Bankstown Lidcombe Hospital · AUGriffith University · AURoyal Prince Alfred Hospital · AUThe University of Queensland · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasma biomarkers for Parkinson's disease (PD) diagnosis that carry predictive value for cognitive impairment are valuable. We explored the relationship of Mini-Mental State Examination (MMSE) score with plasma biomarkers in PD patients and compared results to vascular dementia (VaD) and normal controls. The predictive accuracy of an individual biomarker on cognitive impairment was evaluated using area under the receiver operating characteristic curve (AUROC), and multivariate logistic regression was applied to evaluate predictive accuracy of biomarkers on cognitive impairment; 178 subjects (41 PD, 31 VaD and 106 normal controls) were included. In multiple linear regression analysis of PD patients, α-synuclein, anti-α-synuclein, α-synuclein/Aβ40 and anti-α-synuclein/Aβ40 were highly predictive of MMSE score in both full model and parsimonious model (R

Indexed as

Cognitive DysfunctionParkinson DiseaseBiomarkersHumansBiomarkersAmyloid-beta40BiomarkersCognitive impairmentMini-Mental State Examination scoreParkinson’s diseaseα-synuclein

Identifiers

PMID35879562
PMCPMC9618522
OpenAlexW4287836514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.