Evidence map›Paper›PMID 35879542›Full record

ReviewNature ecology & evolution2022

Population genetics of clonally transmissible cancers.

Máire Ní Leathlobhair, Richard E Lenski

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature ecology & evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Intergenomic signatures of coevolution between Tasmanian devils and an infectious cancer.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. The devil is in the detail.Nature ecology & evolution · 2024
    Article
  10. Article
  11. The Clinical Significance of Genetic Variation in Ovarian Cancer.International journal of molecular sciences · 2023
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Máire Ní LeathlobhairBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK. mnileathlobhair@gmail.com.ORCID http://orcid.org/0000-0002-8523-4935
Richard E LenskiDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA.ORCID http://orcid.org/0000-0002-1064-8375

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Populations of cancer cells are subject to the same core evolutionary processes as asexually reproducing, unicellular organisms. Transmissible cancers are particularly striking examples of these processes. These unusual cancers are clonal lineages that can spread through populations via physical transfer of living cancer cells from one host individual to another, and they have achieved long-term success in the colonization of at least eight different host species. Population genetic theory provides a useful framework for understanding the shift from a multicellular sexual animal into a unicellular asexual clone and its long-term effects on the genomes of these cancers. In this Review, we consider recent findings from transmissible cancer research with the goals of developing an evolutionarily informed perspective on transmissible cancers, examining possible implications for their long-term fate and identifying areas for future research on these exceptional lineages.

Indexed as

Genetics, PopulationNeoplasmsAnimalsBiological EvolutionGenomePopulation Dynamics

Identifiers

PMID35879542

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.