ReviewNature metabolism2022
Acts of appetite: neural circuits governing the appetitive, consummatory, and terminating phases of feeding.
Review in Nature metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
87 citing papers in PubMed, 144 citations in OpenAlex.
- The claustrum encodes and scales appetitive feeding.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Representations of the intrinsic value of information in mouse orbitofrontal cortex.Nature neuroscience · 2026Article
- Dual-Organelle Secretome Conjugation and Organ-Uptake Tracking (DuO-SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The critical role of gut-brain signalling in eating behaviour and obesity.Nature reviews. Gastroenterology & hepatology · 2026Review
- Neural Decision-Making and Affective Dynamics in Weight Regain after Metabolic and Bariatric Surgery: A Multimodal Longitudinal Computational Psychiatry Study.Obesity surgery · 2026Article
- Peptide Hormones in Appetite Regulation: A Complex Network.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Article
- Emerging role of AgRP neurons as integrators of metabolic, sensory and environmental cues in the control of energy homeostasis.Reviews in endocrine & metabolic disorders · 2026Review
- Glycogen drives the sensory activation of POMC neurons.Nature metabolism · 2026Article
- Intestinal obstruction impairs feeding and promotes sleep inScience advances · 2026Article
- A Preoptic Neuronal Population Regulates Energy Expenditure and Balance.bioRxiv : the preprint server for biology · 2026Article
- Top-down regulation of ingestive behavior fragmentation.bioRxiv : the preprint server for biology · 2026Article
- Neuropeptide Y and peptide YY differentially modulate bitter- and fatty acid-evoked responses in human fungiform taste bud cells.American journal of physiology. Cell physiology · 2026Article
- Mechanisms that create a sequence of feeding-related behaviors in the molluskJournal of neurophysiology · 2026Article
- Host genomic regulation of ileal Bradyrhizobium abundance modulates eating speed and fat metabolism in birds: a causal mechanism study.Journal of animal science and biotechnology · 2026Article
- Bright light exposure suppresses feeding and weight gain via a visual circuit linked to the lateral hypothalamus.Nature neuroscience · 2026Article
- Obesogenic effects of warm temperature involve feeding adaptation by preoptic area leptin receptor neurons.Communications biology · 2026Article
- Cellular coding of ingestion in the caudal brainstem.bioRxiv : the preprint server for biology · 2026Article
- An exploratory microarray analysis of estrogen-mediated gene expression in central pathways that control energy balance in female rats (Rattus norvegicus).BMC research notes · 2026Article
- THIK-1 channel mediates microglial glucose sensing and modulates AgRP neurons.bioRxiv : the preprint server for biology · 2026Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The overconsumption of highly caloric and palatable foods has caused a surge in obesity rates in the past half century, thereby posing a healthcare challenge due to the array of comorbidities linked to heightened body fat accrual. Developing treatments to manage body weight requires a grasp of the neurobiological basis of appetite. In this Review, we discuss advances in neuroscience that have identified brain regions and neural circuits that coordinate distinct phases of eating: food procurement, food consumption, and meal termination. While pioneering work identified several hypothalamic nuclei to be involved in feeding, more recent studies have explored how neuronal populations beyond the hypothalamus, such as the mesolimbic pathway and nodes in the hindbrain, interconnect to modulate appetite. We also examine how long-term exposure to a calorically dense diet rewires feeding circuits and alters the response of motivational systems to food. Understanding how the nervous system regulates eating behaviour will bolster the development of medical strategies that will help individuals to maintain a healthy body weight.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.