Evidence map›Paper›PMID 35879431›Full record

ArticleCommunications biology2022

Multimodal anatomy of the human forniceal commissure.

Kevin Akeret, Stephanie J Forkel, Raphael M Buzzi, Flavio Vasella, Irmgard Amrein, Giovanni Colacicco, Carlo Serra, Niklaus Krayenbühl

Abstract read
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kevin AkeretDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Stephanie J ForkelBrain Connectivity and Behaviour Laboratory, Sorbonne Universities, Paris, France.ORCID 0000-0003-0493-0283
Raphael M BuzziDivision of Internal Medicine, University Hospital Zurich and University of Zurich, Zurich, Switzerland.ORCID 0000-0002-9584-3590
Flavio VasellaDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Irmgard AmreinInstitute of Anatomy, University of Zurich, Zurich, Switzerland.
Giovanni ColaciccoInstitute of Anatomy, University of Zurich, Zurich, Switzerland.
Carlo SerraDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Niklaus KrayenbühlDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland. niklaus.krayenbuehl@kispi.uzh.ch.ORCID 0000-0003-1089-221X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ambiguity surrounds the existence and morphology of the human forniceal commissure. We combine advanced in-vivo tractography, multidirectional ex-vivo fiber dissection, and multiplanar histological analysis to characterize this structure's anatomy. Across all 178 subjects, in-vivo fiber dissection based on the Human Connectome Project 7 T MRI data identifies no interhemispheric connections between the crura fornicis. Multidirectional ex-vivo fiber dissection under the operating microscope demonstrates the psalterium as a thin soft-tissue membrane spanning between the right and left crus fornicis, but exposes no commissural fibers. Multiplanar histological analysis with myelin and Bielchowsky silver staining, however, visualizes delicate cruciform fibers extending between the crura fornicis, enclosed by connective tissue, the psalterium. The human forniceal commissure is therefore much more delicate than previously described and presented in anatomical textbooks. This finding is consistent with the observed phylogenetic trend of a reduction of the forniceal commissure in non-human primates compared to non-primate eutherian mammals.

Indexed as

ConnectomeAnimalsHumansMagnetic Resonance ImagingMammalsMyelin SheathPhylogeny

Identifiers

PMID35879431
PMCPMC9314404

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.