ArticleScientific reports2022
Polarimetric biomarkers of peri-tumoral stroma can correlate with 5-year survival in patients with left-sided colorectal cancer.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Label-free differentiation of classical and hypermobile Ehlers-Danlos syndromes using Mueller matrix polarimetry.Biophotonics discovery · 2026Article
- Machine learning-based prediction of luminal breast cancer subtypes using polarised light microscopy.British journal of cancer · 2025Article
- Investigation of potential prognostic biomarkers for colorectal cancer.Archives of medical science : AMS · 2025Article
- Machine learning based local recurrence prediction in colorectal cancer using polarized light imaging.Journal of biomedical optics · 2024Article
- Mueller matrix polarization parameters correlate with local recurrence in patients with stage III colorectal cancer.Scientific reports · 2023Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Using a novel variant of polarized light microscopy for high-contrast imaging and quantification of unstained histology slides, the current study assesses the prognostic potential of peri-tumoral collagenous stroma architecture in 32 human stage III colorectal cancer (CRC) patient samples. We analyze three distinct polarimetrically-derived images and their associated texture features, explore different unsupervised clustering algorithm models to group the data, and compare the resultant groupings with patient survival. The results demonstrate an appreciable total accuracy of ~ 78% with significant separation (p < 0.05) across all approaches for the binary classification of 5-year patient survival outcomes. Surviving patients preferentially belonged to Cluster 1 irrespective of model approach, suggesting similar stromal microstructural characteristics in this sub-population. The results suggest that polarimetrically-derived stromal biomarkers may possess prognostic value that could improve clinical management/treatment stratification in CRC patients.
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