ArticleNature communications2022
Noise correlations in neural ensemble activity limit the accuracy of hippocampal spatial representations.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Population coding under the scale invariance of high-dimensional noise.Science advances · 2026Article
- Network-Level Characterization of Spontaneous Calcium Activity in an In-Vitro Alzheimer's Disease Model.bioRxiv : the preprint server for biology · 2026Article
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- Deciphering hippocampal place codes in weak theta rhythms.Nature communications · 2026Article
- Functional specialisation of multisensory temporal integration in the mouse superior colliculus.Nature communications · 2025Article
- Learning-Associated Flexibility of Cortical Taste Coding Is Impaired in Shank3 Knockout Mice.bioRxiv : the preprint server for biology · 2025Article
- Disentangling signal and noise in neural responses through generative modeling.PLoS computational biology · 2025Article
- Extending Mathematical Frameworks to Investigate Neuronal Dynamics in the Presence of Microglial Ensheathment.Bulletin of mathematical biology · 2025Article
- Differential Encoding of Two-Tone Harmonics in the Male and Female Mouse Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Disentangling signal and noise in neural responses through generative modeling.bioRxiv : the preprint server for biology · 2024Article
- Adult neurogenesis improves spatial information encoding in the mouse hippocampus.Nature communications · 2024Article
- Distinctive Neurophysiological Signatures of Analgesia after Inflammatory Pain in the ACC of Freely Moving Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Remapping revisited: how the hippocampus represents different spaces.Nature reviews. Neuroscience · 2024Review
- Primacy of vision shapes behavioral strategies and neural substrates of spatial navigation in marmoset hippocampus.Nature communications · 2024Article
- Gamma oscillatory complexity conveys behavioral information in hippocampal networks.Nature communications · 2024Article
- The potential of muscarinic MFrontiers in psychiatry · 2024Review
- The Structure of Hippocampal CA1 Interactions Optimizes Spatial Coding across Experience.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- How our understanding of memory replay evolves.Journal of neurophysiology · 2023Review
- Characterizing neural coding performance for populations of sensory neurons: comparing a weighted spike distance metrics to other analytical methods.Frontiers in neuroscience · 2023Article
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Authors and funding
6 authors.
Funding
Abstract
Neurons in the CA1 area of the mouse hippocampus encode the position of the animal in an environment. However, given the variability in individual neurons responses, the accuracy of this code is still poorly understood. It was proposed that downstream areas could achieve high spatial accuracy by integrating the activity of thousands of neurons, but theoretical studies point to shared fluctuations in the firing rate as a potential limitation. Using high-throughput calcium imaging in freely moving mice, we demonstrated the limiting factors in the accuracy of the CA1 spatial code. We found that noise correlations in the hippocampus bound the estimation error of spatial coding to ~10 cm (the size of a mouse). Maximal accuracy was obtained using approximately [300-1400] neurons, depending on the animal. These findings reveal intrinsic limits in the brain's representations of space and suggest that single neurons downstream of the hippocampus can extract maximal spatial information from several hundred inputs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.