ArticleNature communications2022
Cell landscape of larval and adult Xenopus laevis at single-cell resolution.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed.
- Conserved and lineage-specific mechanisms drive chromatophore differentiation in reptiles.Nature communications · 2026Article
- A thyroid hormone-mediated opsin switch initiates metamorphosis in a proto-vertebrate.Science advances · 2026Article
- Cross-species comparison of amniote single-cell transcriptomes reveals evolutionary conservation and divergence in the chicken immune system.Nature communications · 2026Article
- MafB is a conserved transcriptional regulator of macrophage development and functional identity across tissues and species.Immunity · 2026Article
- Immune regulation and cellular crosstalk drive non-fibrotic lung remodeling in pre-metamorphic frogs exposed to paraquat.BMC biology · 2026Article
- Construction of a Multitissue Cell Atlas Reveals Cell-Type-Specific Regulation of Molecular and Complex Phenotypes in Pigs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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- scGeneBank: cross-species screening of functional gene sets at single-cell resolution.Nucleic acids research · 2026Article
- TheBiomolecules · 2025Review
- Microglia across evolution: from conserved origins to functional divergence.Cellular & molecular immunology · 2025Review
- Review
- An epigenetic clock for Xenopus tropicalis.npj aging · 2025Article
- Comparative transcriptomic insights into the evolution of vertebrate photoreceptor types.Current biology : CB · 2025Article
- Advances and applications in single-cell and spatial genomics.Science China. Life sciences · 2025Review
- Article
- Single-nucleus transcriptional and chromatin accessible profiles reveal critical cell types and molecular architecture underlying chicken sex determination.Journal of advanced research · 2025Article
- Cross-species imputation and comparison of single-cell transcriptomic profiles.Genome biology · 2025Article
- scQA: A dual-perspective cell type identification model for single cell transcriptome data.Computational and structural biotechnology journal · 2024Article
- Comparative transcriptomic insights into the evolutionary origin of the tetrapod double cone.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rapid development of high-throughput single-cell RNA sequencing technology offers a good opportunity to dissect cell heterogeneity of animals. A large number of organism-wide single-cell atlases have been constructed for vertebrates such as Homo sapiens, Macaca fascicularis, Mus musculus and Danio rerio. However, an intermediate taxon that links mammals to vertebrates of more ancient origin is still lacking. Here, we construct the first Xenopus cell landscape to date, including larval and adult organs. Common cell lineage-specific transcription factors have been identified in vertebrates, including fish, amphibians and mammals. The comparison of larval and adult erythrocytes identifies stage-specific hemoglobin subtypes, as well as a common type of cluster containing both larval and adult hemoglobin, mainly at NF59. In addition, cell lineages originating from all three layers exhibits both antigen processing and presentation during metamorphosis, indicating a common regulatory mechanism during metamorphosis. Overall, our study provides a large-scale resource for research on Xenopus metamorphosis and adult organs.
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