ArticleJournal of cardiovascular imaging2022
What Is Normal for an Aging Heart?: A Prospective CMR Cohort Study.
Article in Journal of cardiovascular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Society for Cardiovascular Magnetic Resonance reference values ("normal values") in cardiovascular magnetic resonance: 2025 update.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025Guideline
- Cardiac magnetic resonance in heart transplant recipients: histological, clinical and cell-free DNA validation.European heart journal. Cardiovascular Imaging · 2025Trial
- Sex-specific structural and functional cardiac remodeling during healthy aging assessed by cardiovascular magnetic resonance.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Physiological assessment of left ventricular size indexed by peak oxygen uptake across sporting disciplines.European heart journal. Imaging methods and practice · 2025Article
- Cardiovascular magnetic resonance imaging markers of ageing: a multi-centre, cross-sectional cohort study.European heart journal open · 2025Article
- Long-term impact of anthracycline in early-stage breast cancer, bridging of MiRNAs profiler for early cardiotoxicity.Cardio-oncology (London, England) · 2025Article
- The aging heart: exploring the role of Klotho in cardiac health/function.The journal of cardiovascular aging · 2024Article
- Three-Dimensional Feature Tracking Study of Healthy Chinese Ventricle by Cardiac Magnetic Resonance.Cardiovascular engineering and technology · 2024Article
- Cardiovascular Aging and Risk Assessment: How Multimodality Imaging Can Help.Diagnostics (Basel, Switzerland) · 2024Review
- Misclassification of females and males in cardiovascular magnetic resonance parametric mapping: the importance of sex-specific normal ranges for diagnosis of health vs. disease.European heart journal. Cardiovascular Imaging · 2024Article
- CMR reveals myocardial damage from cardiotoxic oncologic therapies in breast cancer patients.The international journal of cardiovascular imaging · 2024Article
- Image-Based Biological Heart Age Estimation Reveals Differential Aging Patterns Across Cardiac Chambers.Journal of magnetic resonance imaging : JMRI · 2023Article
- Effect of Aging on Intraventricular Kinetic Energy and Energy Dissipation.Journal of cardiovascular development and disease · 2023Review
- The Role of Echocardiography in Evaluating Cardiovascular Diseases in Patients with Diabetes Mellitus.Diabetes & metabolism journal · 2023Review
- Cardiac Magnetic Resonance in the Aging Heart.Journal of cardiovascular imaging · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThis study aims to investigate normal changes throughout aging of the heart in cardiac magnetic resonance (CMR) imaging in healthy volunteers. While type 2 diabetes mellitus is a frequent finding in the elderly population, also the influence of this circumstance in otherwise healthy persons is part of our study.
methodsIn this prospective single-center trial, 75 healthy subjects in distinct age groups and 10 otherwise healthy diabetics were enrolled. All subjects underwent functional, flow sensitive, native T2- and T1-mapping in a 1.5T CMR scanner.
resultsNo differences in right and left ventricular ejection fractions were observed between aging healthy groups. Bi-ventricular volumes lowered significantly (p<0.001) between the age groups. There was also a significant decrease in myocardial T1 values, aortic distensibility, and left ventricular peak diastolic strain rates. There were no differences in T2 mapping and the other deformation parameters. Patients with type 2 diabetes mellitus had lower end-diastolic volume indexes; all the other measurements were comparable.
conclusionsAging processes in the healthy heart involve a decrease in ventricular volumes, with ejection fractions remaining normal. Stiffening of the myocardium and aorta and a decrease in T1 values are potential indications of age-related remodeling. Type 2 diabetes mellitus seems to have no major influence on aging processes of the heart.
trial registrationEudraCT Identifier: EudraCT 2017-000045-42.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.