Evidence map›Paper›PMID 35878164›Full record

ArticleToxins2022

Natural and Induced Tolerance to Hymenoptera Venom: A Single Mechanism?

Ana Navas, Berta Ruiz-Leon, Pilar Serrano, Manuel Martí, M Luisa Espinazo, Nadine Blanco, Juan Molina, Corona Alonso, Aurora Jurado, Carmen Moreno-Aguilar

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Hymenoptera Venom Immunotherapy in Dogs: Safety and Clinical Efficacy.Animals : an open access journal from MDPI · 2023
    Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ana NavasUGC Inmunología-Alergología, Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain.
Berta Ruiz-LeonUGC Inmunología-Alergología, Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain.
Pilar SerranoUGC Inmunología-Alergología, Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain.
Manuel MartíPharmacology Department, Institute of Molecular Pathology Biomarkers, University of Extremadura (UEx), ARADyAL INS Carlos III, 10071 Cáceres, Spain.
M Luisa EspinazoGC01 Inmunología y Alergología Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, ARADyAL INS Carlos III, 14004 Cordoba, Spain.
Nadine BlancoUGC Inmunología-Alergología, Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain.ORCID 0000-0002-7684-5099
Juan MolinaUGC Inmunología-Alergología, Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain.
Corona AlonsoUGC Inmunología-Alergología, Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain.
Aurora JuradoUGC Inmunología-Alergología, Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain.ORCID 0000-0001-9092-8758
Carmen Moreno-AguilarUGC Inmunología-Alergología, Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain.
Instituto Maimónides de Investigación Biomédica de Córdoba · ESUniversidad de Extremadura · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inducing tolerance in Hymenoptera-allergic patients, bee venom immunotherapy (BVIT) is a widely accepted method to treat severe allergy to bee stings. In order to increase the existing knowledge on the underlying immunological mechanisms and look for possible biomarkers predictive of efficacy, a group of 20 bee-venom-allergic patients (AG) were thoroughly examined during their first year of BVIT. In addition, the results of treated patients with those of an untreated group of 20 tolerant beekeepers (TG) who had previously shown a firm suppressor-regulatory profile were compared. Tolerance in AG patients was invariably associated with a significant regulatory response characterised by the expansion of Helios

Indexed as

Arthropod VenomsBee VenomsHymenopteraHypersensitivityInsect Bites and StingsAnimalsBeesBiomarkersDesensitization, ImmunologicKynurenineArthropod VenomsBee VenomsBiomarkersKynurenineanaphylaxisbee venom immunotherapyHelios proteinkynureninetolerance

Identifiers

PMID35878164
PMCPMC9320229
OpenAlexW4283324900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.