ArticleProceedings of the National Academy of Sciences of the United States of America2022
Modeling reveals posttranscriptional regulation of GA metabolism enzymes in response to drought and cold.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 15 citations in OpenAlex.
- Genetic Characterization of RNA Recognition Motif (RRM)-Containing Genes in Coconut Palm.Plants (Basel, Switzerland) · 2026Article
- A balance of metabolism and diffusion articulates a gibberellin hormone gradient in theProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Unlocking grass leaf development: foundations for tunable cereal design.The New phytologist · 2025Review
- Transcriptomic analysis of melatonin-mediated drought stress response genes in alfalfa during germination period.BMC plant biology · 2025Article
- Unraveling the response of secondary metabolites to cold tolerance in oil palm by integration of physiology and metabolomic analyses.BMC plant biology · 2025Article
- Drought-induced molecular changes in crown of various barley phytohormone mutants.Plant signaling & behavior · 2024Article
- Expression analysis of the apple HSP70 gene family in abiotic stress and phytohormones and expression validation of candidate MdHSP70 genes.Scientific reports · 2024Article
- Article
- Multiscale Asymptotic Analysis Reveals How Cell Growth and Subcellular Compartments Affect Tissue-Scale Hormone Transport.Bulletin of mathematical biology · 2023Article
- Recent Advances in the Bacterial Phytohormone Modulation of Plant Growth.Plants (Basel, Switzerland) · 2023Article
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hormone gibberellin (GA) controls plant growth and regulates growth responses to environmental stress. In monocotyledonous leaves, GA controls growth by regulating division-zone size. We used a systems approach to investigate the establishment of the GA distribution in the maize leaf growth zone to understand how drought and cold alter leaf growth. By developing and parameterizing a multiscale computational model that includes cell movement, growth-induced dilution, and metabolic activities, we revealed that the GA distribution is predominantly determined by variations in GA metabolism. Considering wild-type and UBI::GA20-OX-1 leaves, the model predicted the peak in GA concentration, which has been shown to determine division-zone size. Drought and cold modified enzyme transcript levels, although the model revealed that this did not explain the observed GA distributions. Instead, the model predicted that GA distributions are also mediated by posttranscriptional modifications increasing the activity of GA 20-oxidase in drought and of GA 2-oxidase in cold, which we confirmed by enzyme activity measurements. This work provides a mechanistic understanding of the role of GA metabolism in plant growth regulation.
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