Evidence map›Paper›PMID 35878038›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Arrestin-mediated desensitization enables intraneuronal olfactory discrimination in

Daniel M Merritt, Isabel MacKay-Clackett, Sylvia M T Almeida, Celina Tran, Safa Ansar, Derek van der Kooy

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. β-arrestins Are Scaffolding Proteins Required for Shh-Mediated Axon Guidance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Daniel M MerrittInstitute for Medical Science, University of Toronto, Toronto, M5S 3E2 ON, Canada.ORCID 0000-0001-6273-6644
Isabel MacKay-ClackettInstitute for Medical Science, University of Toronto, Toronto, M5S 3E2 ON, Canada.
Sylvia M T AlmeidaDepartment of Molecular Genetics, University of Toronto, Toronto, M5S 3E2 ON, Canada.ORCID 0000-0002-5652-5792
Celina TranDepartment of Molecular Genetics, University of Toronto, Toronto, M5S 3E2 ON, Canada.
Safa AnsarDepartment of Molecular Genetics, University of Toronto, Toronto, M5S 3E2 ON, Canada.
Derek van der KooyInstitute for Medical Science, University of Toronto, Toronto, M5S 3E2 ON, Canada.ORCID 0000-0001-9927-9432
University of Toronto · CA

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

In the mammalian olfactory system, cross-talk between olfactory signals is minimized through physical isolation: individual neurons express one or few olfactory receptors among those encoded in the genome. Physical isolation allows for segregation of stimuli during signal transduction; however, in the nematode worm

Indexed as

Caenorhabditis elegans ProteinsOlfactory Receptor NeuronsReceptors, OdorantAnimalsArrestinbeta-Arrestin 1beta-ArrestinsCaenorhabditis elegansMammalsSensory Receptor CellsArrestinbeta-Arrestin 1beta-ArrestinsCaenorhabditis elegans ProteinsReceptors, OdorantarrestindiscriminationGRK-1olfactionsignaling

Identifiers

PMID35878038
PMCPMC9351366
OpenAlexW4287577375

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.