Evidence map›Paper›PMID 35878031›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Regulated processing and secretion of a peptide precursor in cilia.

Raj Luxmi, Richard E Mains, Betty A Eipper, Stephen M King

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Heme-binding protein CYB5D1 couples intraflagellar redox to calcium signaling for coordinated flagellar beating.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Comparative Proteomics of Plasma and Flagellar Membranes inInternational journal of molecular sciences · 2026
    Article
  5. Review
  6. The methylome of motile cilia.Molecular biology of the cell · 2024
    Article
  7. Review
  8. Review
  9. Regulated processing and secretion of a peptide precursor in cilia.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Raj LuxmiDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT 06030-3305.ORCID 0000-0003-1554-0723
Richard E MainsDepartment of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030-3305.ORCID 0000-0003-1154-1331
Betty A EipperDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT 06030-3305.ORCID 0000-0003-1171-5557
Stephen M KingDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT 06030-3305.ORCID 0000-0002-5484-5530
UConn Health · US

Funding

BIOCHEMISTRY AND PHYSIOLOGY OF PEPTIDE AMIDATIONR01DK032949 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI EIPPER, ELIZABETH ANNE, KING, STEPHEN M · 1986 to 2017
$6.4M
The Biology of Motile CiliaR35GM140631 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Stephen M King · 2021 to 2026
$4.2M
BIOCHEMISTRY AND PHYSIOLOGY OF PEPTIDE AMIDATIONR37DK032949 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI EIPPER, ELIZABETH A · 1989 to 2004
$2.8M
Peptide Amidation in CiliogenesisR01GM125606 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KING, STEPHEN M · 2019 to 2021
$1.3M
BIOCHEMISTRY AND PHYSIOLOGY OF PEPTIDE AMIDATIONR56DK032949 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI EIPPER, ELIZABETH A · 2005 to 2005
$104k
NIDDK NIH HHS R01 DK032949NIDDK NIH HHS R37 DK032949NIDDK NIH HHS R56 DK032949NIGMS NIH HHS R01 GM125606NIGMS NIH HHS R35 GM140631
6 · The paper itself

Abstract

Cilia are sensory and secretory organelles that both receive information from the environment and transmit signals. Cilia-derived vesicles (ectosomes), formed by outward budding of the ciliary membrane, carry enzymes and other bioactive products; this process represents an ancient mode of regulated secretion. Peptidergic intercellular communication controls a wide range of physiological and behavioral responses and occurs throughout eukaryotes. The

Indexed as

Cell-Derived MicroparticlesChlamydomonas reinhardtiiCiliaPeptidesAnimalsCell CommunicationPeptidesamidationchemotaxisChlamydomonasectosomespeptidergic signaling

Identifiers

PMID35878031
PMCPMC9351486
OpenAlexW4287577181

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.