Evidence map›Paper›PMID 35878027›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

A gut microbial peptide and molecular mimicry in the pathogenesis of type 1 diabetes.

Khyati Girdhar, Qian Huang, I-Ting Chow, Tommi Vatanen, Claudia Brady, Amol Raisingani, Patrick Autissier, Mark A Atkinson, William W Kwok, C Ronald Kahn and 1 more

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
15.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 85 citations in OpenAlex.

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  8. [Gut microbiota dysbiosis in type 1 diabetes mellitus: Impacts, mechanisms, and interventions].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Khyati GirdharBiology Department, Boston College, Chestnut Hill, MA 02467.
Qian HuangBiology Department, Boston College, Chestnut Hill, MA 02467.
I-Ting ChowBenaroya Research Institute at Virginia Mason, Seattle, WA 98101.ORCID 0000-0001-7278-8157
Tommi VatanenThe Liggins Institute, University of Auckland, Auckland 1023, New Zealand.
Claudia BradyBiology Department, Boston College, Chestnut Hill, MA 02467.
Amol RaisinganiBiology Department, Boston College, Chestnut Hill, MA 02467.
Patrick AutissierBiology Department, Boston College, Chestnut Hill, MA 02467.
Mark A AtkinsonDepartment of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida Diabetes Institute, Gainesville, FL 32610-3633.
William W KwokBenaroya Research Institute at Virginia Mason, Seattle, WA 98101.
C Ronald KahnJoslin Diabetes Center, Harvard Medical School, Boston, MA 02215.ORCID 0000-0002-7583-9228
Emrah AltindisBiology Department, Boston College, Chestnut Hill, MA 02467.
Boston College · USVirginia Mason Medical Center · USBroad Institute · USJoslin Diabetes Center · USUniversity of Florida · US

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
Project 3P01AI042288 · NIAID · UNIVERSITY OF FLORIDA · PI Todd Michael Brusko · 1997 to 2026
$32.9M
The Insulin Receptor and Its Signaling MechanismsR01DK031036 · NIDDK · JOSLIN DIABETES CENTER · PI C RONALD KAHN · 1986 to 2026
$4.2M
Interaction between genes, environment, the microbiome and metabolome in type 2 diabetes and metabolic syndromeR01DK121967 · NIDDK · JOSLIN DIABETES CENTER · PI KAHN, C RONALD · 2020 to 2024
$2.7M
Viral Insulin-like Peptides (VILPs) and Their Activities on Mammalian CellsK01DK117967 · NIDDK · JOSLIN DIABETES CENTER · PI ALTINDIS, EMRAH · 2018 to 2021
$445k
NIAID NIH HHS P01 AI042288NIDDK NIH HHS K01 DK117967NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK031036NIDDK NIH HHS R01 DK121967
6 · The paper itself

Abstract

Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of pancreatic β-cells. One of the earliest aspects of this process is the development of autoantibodies and T cells directed at an epitope in the B-chain of insulin (insB:9-23). Analysis of microbial protein sequences with homology to the insB:9-23 sequence revealed 17 peptides showing >50% identity to insB:9-23. Of these 17 peptides, the

Indexed as

Diabetes Mellitus, Type 1Gastrointestinal MicrobiomeMolecular MimicryPeptidesAnimalsAutoantibodiesBacteroidetesCD8-Positive T-LymphocytesChildFemaleHumansInsulinMiceMice, Inbred NODMice, SCIDAutoantibodiesInsulinPeptidesgut microbiomeinsB:9-23 epitopemolecular mimicryParabacteroides distasonistype 1 diabetes

Identifiers

PMID35878027
PMCPMC9351354
OpenAlexW4287578522

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.