Evidence map›Paper›PMID 35878004›Full record

ArticleACS nano2022

Protease-Responsive Peptide-Conjugated Mitochondrial-Targeting AIEgens for Selective Imaging and Inhibition of SARS-CoV-2-Infected Cells.

Yong Cheng, Alex E Clark, Jiajing Zhou, Tengyu He, Yi Li, Raina M Borum, Matthew N Creyer, Ming Xu, Zhicheng Jin, Jingcheng Zhou and 6 more

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 43 citations in OpenAlex.

  1. Chemistry of materials : a publication of the American Chemical Society · 2025
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Yong ChengDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, United States.
Alex E ClarkDepartment of Medicine, University of California, San Diego, La Jolla, California 92093, United States.
Jiajing ZhouDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, United States.ORCID 0000-0001-5203-4737
Tengyu HeMaterials Science and Engineering Program, University of California, San Diego, La Jolla, California 92093, United States.ORCID 0000-0002-6767-4849
Yi LiDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, United States.
Raina M BorumDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, United States.ORCID 0000-0003-4265-3109
Matthew N CreyerDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, United States.ORCID 0000-0003-1213-8245
Ming XuDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, United States.
Zhicheng JinDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, United States.ORCID 0000-0001-6072-7533
Jingcheng ZhouDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, United States.
Wonjun YimMaterials Science and Engineering Program, University of California, San Diego, La Jolla, California 92093, United States.ORCID 0000-0002-0242-7898
Zhuohong WuDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, United States.
Pavla FajtováSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States.
Anthony J O'DonoghueSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States.
Aaron F CarlinDepartment of Medicine, University of California, San Diego, La Jolla, California 92093, United States.
Jesse V JokerstDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, United States.
University of California San Diego · US

Funding

Validation of Smart Masks for Surveillance of COVID-19R01DE031114 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2021 to 2023
$1.2M
Deconvolution of pro- and anti-viral responses to Dengue virus and Zika Virus infectionsK08AI130381 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CARLIN, AARON F. · 2019 to 2023
$1.0M
Cancer Researchers in Nanotechnology (CRIN)T32CA153915 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUMMEL, ANDREW CLYDE, ZHANG, DONG-ER · 2017 to 2021
$994k
Non-Invasive Detection and Staging of Decubitus and Diabetic UlcersR21AG065776 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2020 to 2021
$575k
Imaging SARS-CoV-2 proteases for spatio-temporal insight into Covid-19R21AI157957 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2020 to 2020
$434k
NCI NIH HHS T32 CA153915NIAID NIH HHS K08 AI130381NIAID NIH HHS R21 AI157957NIA NIH HHS R21 AG065776NIDCR NIH HHS R01 DE031114
6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a serious threat to human health and lacks an effective treatment. There is an urgent need for both real-time tracking and precise treatment of the SARS-CoV-2-infected cells to mitigate and ultimately prevent viral transmission. However, selective triggering and tracking of the therapeutic process in the infected cells remains challenging. Here, we report a main protease (M

Indexed as

COVID-19SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesHumansPeptidesAntiviral AgentsCoronavirus 3C ProteasesPeptidesmain proteasemitochondrial targetingpeptide-conjugated AIEgenSARS-CoV-2virus theranostics

Identifiers

PMID35878004
PMCPMC9344892
OpenAlexW4287578219

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.