Evidence map›Paper›PMID 35877881›Full record

ArticleMembranes2022

Design of a Sensitive Extracellular Vesicle Detection Method Utilizing a Surface-Functionalized Power-Free Microchip.

Ryo Ishihara, Asuka Katagiri, Tadaaki Nakajima, Ryo Matsui, Kazuo Hosokawa, Mizuo Maeda, Yasuhiro Tomooka, Akihiko Kikuchi

Abstract read
In one paragraph

Article in Membranes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ryo IshiharaFaculty of Medicine, Juntendo University, Chiba 270-1695, Japan.ORCID 0000-0003-4862-4843
Asuka KatagiriDepartment of Materials Science and Technology, Tokyo University of Science, Tokyo 125-8585, Japan.
Tadaaki NakajimaDepartment of Bioengineering and Technology, Tokyo University of Science, Tokyo 125-8585, Japan.ORCID 0000-0002-4189-1837
Ryo MatsuiDepartment of Materials Science and Technology, Tokyo University of Science, Tokyo 125-8585, Japan.
Kazuo HosokawaBioengineering Laboratory, RIKEN Cluster for Pioneering Research, RIKEN, Saitama 351-0198, Japan.
Mizuo MaedaBioengineering Laboratory, RIKEN Cluster for Pioneering Research, RIKEN, Saitama 351-0198, Japan.
Yasuhiro TomookaDepartment of Bioengineering and Technology, Tokyo University of Science, Tokyo 125-8585, Japan.
Akihiko KikuchiDepartment of Materials Science and Technology, Tokyo University of Science, Tokyo 125-8585, Japan.ORCID 0000-0002-7814-3656

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs), which are small membrane vesicles secreted from cells into bodily fluids, are promising candidates as biomarkers for various diseases. We propose a simple, highly sensitive method for detecting EVs using a microchip. The limit of detection (LOD) for EVs was improved 29-fold by changing the microchannel structure of the microchip and by optimizing the EV detection protocols. The height of the microchannel was changed from 25 to 8 µm only at the detection region, and the time for EV capture was extended from 5 to 10 min. The LOD was 6.3 × 10

Indexed as

cancersdetection sensitivityextracellular vesiclespoint-of-care testingsurface-functionalized power-free microchip

Identifiers

PMID35877881
PMCPMC9323264

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.