ArticleMarine drugs2022
Sulfated Polysaccharide Extracted from the Green Algae
Article in Marine drugs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 64 citations in OpenAlex.
- Bombyx mori-Hosted Cordyceps militaris Polysaccharides: Structural Characterization and Antibacterial Activity of Native and Sulfated Derivatives.Chemistry & biodiversity · 2026Article
- Water-soluble sulfated exopolysaccharide from Cytobacillus oceanisediminis: Its production, characterization and biological activities.Folia microbiologica · 2026Article
- Bioactive Sulfated Polysaccharides from Green AlgaeInternational journal of molecular sciences · 2026Article
- Ulvan from Ulva lactuca Promotes Keratinocyte Migration, Adhesion, and Photoprotection Against UVB Damage.Marine biotechnology (New York, N.Y.) · 2026Article
- Protective Effects of Polysaccharides fromFoods (Basel, Switzerland) · 2026Article
- Anti-Neuroinflammatory Effects of a Representative Low-Molecular-Weight Component Isolated fromMarine drugs · 2026Article
- ROS-mediated apoptosis in colon cancer cells induced by sulfated polysaccharides from Gracilaria corticata.PloS one · 2026Article
- Polysaccharide-based anticancer therapeutics: molecular mechanisms, translational advances, and the road toward precision oncology.Frontiers in pharmacology · 2026Review
- Past and Present of the Antioxidant Studies in Chile: A Bibliometric Study from 2000 to 2024.Antioxidants (Basel, Switzerland) · 2025Article
- Study on the chemical modification of polysaccharides from3 Biotech · 2025Article
- Article
- Microalgae: A Promising Source of Bioactive Polysaccharides for Biotechnological Applications.Molecules (Basel, Switzerland) · 2025Review
- Sustainable and biocompatible hybrid materials-based sulfated polysaccharides for biomedical applications: a review.RSC advances · 2025Review
- Unlocking the Therapeutic Potential of Algae-Derived Compounds in Hematological Malignancies.Cancers · 2025Review
- Potential Pharmacological Ability of a Novel Marine Polysaccharide Extracted from Tunisian Green AlgaeCurrent pharmaceutical biotechnology · 2025Article
- Exploring the Pharmacological Potential of Carrageenan Disaccharides as Antitumor Agents: An In Silico Approach.Marine drugs · 2024Article
- Polysaccharide sulfotransferases: the identification of putative sequences and respective functional characterisation.Essays in biochemistry · 2024Review
- Structural, Functional, and Bioactive Properties of Sulfated Polysaccharides from Skipjack Tuna Skin as a Function of Drying Techniques.Global challenges (Hoboken, NJ) · 2024Article
- Physicochemical, structural, and biological properties of novel water-soluble polysaccharide derived from the TunisianHeliyon · 2024Article
- Seaweed as a Valuable and Sustainable Resource for Food Packaging Materials.Foods (Basel, Switzerland) · 2024Review
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
Codium bernabei is a green alga that grows on Chilean coasts. The composition of its structural polysaccharides is still unknown. Hence, the aim of this work is to isolate and characterize the hot water extracted polysaccharide fractions. For this purpose, the water extracts were further precipitated in alcohol (TPs) and acid media (APs), respectively. Both fractions were characterized using different physicochemical techniques such as GC-MS, GPC, FTIR, TGA, and SEM. It is confirmed that the extracted fractions are mainly made of sulfated galactan unit, with a degree of sulfation of 19.3% (TPs) and 17.4% (ATs) and a protein content of 3.5% in APs and 15.6% in TPs. Other neutral sugars such as xylose, glucose, galactose, fucose, mannose, and arabinose were found in a molar ratio (0.05:0.6:1.0:0.02:0.14:0.11) for TPs and (0.05:0.31:1.0:0.03:0.1:0.13) for ATs. The molecular weight of the polysaccharide samples was lower than 20 kDa. Both polysaccharides were thermally stable (Tonset > 190 °C) and showed antioxidant activity according to the ABTS•+ and DPPH tests, where TPs fractions had higher scavenging activity (35%) compared to the APs fractions. The PT and APTTS assays were used to measure the anticoagulant activity of the polysaccharide fractions. In general, the PT activity of the TPs and APs was not different from normal plasma values. The exception was the TPs treatment at 1000 µg mL−1 concentration. The APTTS test revealed that clotting time for both polysaccharides was prolonged regarding normal values at 1000 µg mL−1. Finally, the antitumor test in colorectal carcinoma (HTC-116) cell line, breast cancer (MCF-7) and human leukemia (HL-60) cell lines showed the cytotoxic effect of TPs and APs. Those results suggest the potential biotechnological application of sulfate galactan polysaccharides isolated from a Chilean marine resource.
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