ArticlePloS one2022
Time trend analysis of perinatal mortality, stillbirth, and early neonatal mortality of multiple pregnancies for each gestational week from the year 2000 to 2019: A population-based study in Japan.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- A machine learning approach to identify key socio-economic and demographic factors associated with neonatal mortality in Ethiopia.BMC public health · 2026Article
- Association between gestational age and child health and neurodevelopment in twins from a nationwide longitudinal survey in Japan.Scientific reports · 2025Article
- Co-occurrence of maternal anemia and child undernutrition in Ethiopia: multilevel analysis of analysis of EDHS data (2005-2016).BMC public health · 2025Article
- Perinatal outcomes in Malta between 2008 and 2022: a comparison of three 5 yearly epochs.Frontiers in public health · 2025Article
- Article
- Pregnancy with mixed connective tissue disease: Exploration of factors influencing live birth outcomes.PloS one · 2024Article
- Obesity as a potential risk factor for stillbirth: The Japan Environment and Children's Study.Preventive medicine reports · 2023Article
- The use of digital solutions for the reduction of maternal and perinatal mortality: A systematic review.Digital healthReview
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
Multiple pregnancies pose a high risk of morbidity and mortality in both mothers and infants; thus, obtaining reliable information based on a large population is essential to improve management. We used the maternal and child health statistics, which are published annually, from the database of the Ministry of Health, Labor, and Welfare. The data obtained were aggregated in 5-year intervals, and we used them to analyze the proportion of the number of births for each week of pregnancy to the total of each singleton and multiple pregnancy. For perinatal health indicators (perinatal mortality, stillbirth, and neonatal mortality), the obtained data were calculated and plotted on graphs for each week of pregnancy. Moreover, these indicators were calculated by dividing them into first twin and second twin fetuses. Stillbirth weights were aggregated in several groups, and a histogram was displayed. Between 2000 and 2019, there were 21,068,275 live births, 67,666 stillbirths, and 16,443 early neonatal deaths, excluding 7,148 (7,104 singletons, 44 multiple births) cases, in which the exact gestational weeks at birth were unknown. More than 95% of multiple pregnancies were twin births. Perinatal mortality, stillbirth, and early neonatal mortality rates in multiple pregnancies were the lowest at approximately 37 weeks of gestation and lower than those of single pregnancies at approximately 36 weeks of gestation. Perinatal mortality and stillbirth rates were higher during the delivery of the second twins than the first-born twins, but the early neonatal mortality rate remained approximately the same during the delivery of both twins. As the data in the government database are accumulated and published continuously, indicators can be calculated in the future using the method presented in this study. Further, our findings may be useful for policymaking related to managing multiple pregnancies.
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