Evidence map›Paper›PMID 35877617›Full record

ArticlePloS one2022

Assessing the added value of linking electronic health records to improve the prediction of self-reported COVID-19 testing and diagnosis.

Dylan Clark-Boucher, Jonathan Boss, Maxwell Salvatore, Jennifer A Smith, Lars G Fritsche, Bhramar Mukherjee

Abstract read
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dylan Clark-BoucherDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America.
Jonathan BossDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America.
Maxwell SalvatoreDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America.ORCID 0000-0002-3659-1514
Jennifer A SmithDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America.
Lars G FritscheDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America.ORCID 0000-0002-2110-1690
Bhramar MukherjeeDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America.

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
MI-CARES: The Michigan Cancer and Research on the Environment StudyUG3CA267907 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DOLINOY, DANA, MUKHERJEE, BHRAMAR · 2021 to 2022
$2.2M
Statistical and computational methods for rare variant association analysisR01HG008773 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MUKHERJEE, BHRAMAR · 2016 to 2020
$1.9M
NCI NIH HHS P30 CA046592NCI NIH HHS UG3 CA267907NHGRI NIH HHS R01 HG008773
6 · The paper itself

Abstract

Since the beginning of the Coronavirus Disease 2019 (COVID-19) pandemic, a focus of research has been to identify risk factors associated with COVID-19-related outcomes, such as testing and diagnosis, and use them to build prediction models. Existing studies have used data from digital surveys or electronic health records (EHRs), but very few have linked the two sources to build joint predictive models. In this study, we used survey data on 7,054 patients from the Michigan Genomics Initiative biorepository to evaluate how well self-reported data could be integrated with electronic records for the purpose of modeling COVID-19-related outcomes. We observed that among survey respondents, self-reported COVID-19 diagnosis captured a larger number of cases than the corresponding EHRs, suggesting that self-reported outcomes may be better than EHRs for distinguishing COVID-19 cases from controls. In the modeling context, we compared the utility of survey- and EHR-derived predictor variables in models of survey-reported COVID-19 testing and diagnosis. We found that survey-derived predictors produced uniformly stronger models than EHR-derived predictors-likely due to their specificity, temporal proximity, and breadth-and that combining predictors from both sources offered no consistent improvement compared to using survey-based predictors alone. Our results suggest that, even though general EHRs are useful in predictive models of COVID-19 outcomes, they may not be essential in those models when rich survey data are already available. The two data sources together may offer better prediction for COVID severity, but we did not have enough severe cases in the survey respondents to assess that hypothesis in in our study.

Indexed as

COVID-19Electronic Health RecordsCOVID-19 TestingHumansSelf ReportSurveys and Questionnaires

Identifiers

PMID35877617
PMCPMC9312965

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.