Evidence map›Paper›PMID 35877415›Full record

ArticleCurrent issues in molecular biology2022

Amarilis Giaretta de Moraes, Christiane Maria Ayo, Laise Nayana Sala Elpídio, Victor Hugo de Souza, Aléia Harumi Uchibaba Yamanaka, Maurício Lacerda Nogueira, Saulo Duarte Passos, Cinara Cássia Brandão, Luiz Carlos de Mattos, Greicy Cezar do Amaral and 2 more

Open access · goldAbstract read
In one paragraph

Article in Current issues in molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Early Fc-effector antibody signatures impact COVID-19 disease trajectory.medRxiv : the preprint server for health sciences · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Amarilis Giaretta de MoraesPost Graduation Program in Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-270, PR, Brazil.
Christiane Maria AyoLaboratory of Immunogenetics, Department of Molecular Biology, Faculty of Medicine of São José do Rio Preto (FAMERP), São José do Rio Preto 15090-000, SP, Brazil.
Laise Nayana Sala ElpídioPost Graduation Program in Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-270, PR, Brazil.
Victor Hugo de SouzaPost Graduation Program in Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-270, PR, Brazil.ORCID 0000-0002-6620-540X
Aléia Harumi Uchibaba YamanakaPost Graduation Program in Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-270, PR, Brazil.
Maurício Lacerda NogueiraVirology Research Laboratory, Department of Infectious and Parasitic Diseases, Medical School of São José do Rio Preto (FAMERP), São José do Rio Preto 15090-000, SP, Brazil.ORCID 0000-0003-1102-2419
Saulo Duarte PassosDepartment of Pediatrics, Faculty of Medicine of Jundiai (FMJ), Jundiaí 13202-550, SP, Brazil.ORCID 0000-0002-0908-2677
Cinara Cássia BrandãoLaboratory of Immunogenetics, Department of Molecular Biology, Faculty of Medicine of São José do Rio Preto (FAMERP), São José do Rio Preto 15090-000, SP, Brazil.ORCID 0000-0002-4836-3113
Luiz Carlos de MattosLaboratory of Immunogenetics, Department of Molecular Biology, Faculty of Medicine of São José do Rio Preto (FAMERP), São José do Rio Preto 15090-000, SP, Brazil.
Greicy Cezar do Amaral15th Regional of Health of the State of Paraná, Maringá 87030-090, PR, Brazil.
Quirino Alves de Lima NetoPost Graduation Program in Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-270, PR, Brazil.ORCID 0000-0003-3313-7567
Jeane Eliete Laguila VisentainerPost Graduation Program in Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-270, PR, Brazil.
Universidade Estadual de Maringá · BRFaculdade de Medicina de São José do Rio Preto · BRFaculdade de Medicina de Jundiaí · BR

Funding

Araucaria Foundation Proc.nº.10929/2016Coordination for higher Education Staff Development funding code 001Laboratory of Immunogenetics of the State University of Maringá Proc.nº.1589/2017-CSD-UEMSão Paulo Research Foundation FAPESP - 16/05115-9the National Council for Scientific and Technological Development Proc.nº.315124/2018
6 · The paper itself

Abstract

During the 2015-2016 epidemic, Brazil was the country with the highest rate of Zika virus (ZIKV) infection in the Americas. Twenty-nine percent of pregnant women positive for ZIKV exhibited ultrasound scans with fetus anomalies. Human leukocyte antigen-G (HLA-G) exerts immunoregulatory effects by binding to inhibitory receptors, namely LILRB1 and LILRB2, thus preventing mother-fetus rejection and vertical pathogen transmission. The binding of HLA-G to one of its receptors modulates both innate and adaptive immunity. However, in a viral infection, these molecules may behave as pathogenic mediators shifting the pregnancy environment from an anti-inflammatory profile to a pro-inflammatory phenotype. Genetic mutations might be associated with the change in phenotype. This study aimed to explore the possible role of polymorphic sites in

Indexed as

flavivirusHLALILRBSNPsvertical transmissionZIKV

Identifiers

PMID35877415
PMCPMC9317030
OpenAlexW4283649921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.