Evidence map›Paper›PMID 35877383›Full record

ReviewBioengineering (Basel, Switzerland)2022

Gelatin Methacryloyl Hydrogels for Musculoskeletal Tissue Regeneration.

Yang-Hee Kim, Jonathan I Dawson, Richard O C Oreffo, Yasuhiko Tabata, Dhiraj Kumar, Conrado Aparicio, Isha Mutreja

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yang-Hee KimBone and Joint Research Group, Centre for Human Development, Stem Cells & Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton SO16 6YD, UK.ORCID 0000-0002-5312-3448
Jonathan I DawsonBone and Joint Research Group, Centre for Human Development, Stem Cells & Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton SO16 6YD, UK.
Richard O C OreffoBone and Joint Research Group, Centre for Human Development, Stem Cells & Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton SO16 6YD, UK.ORCID 0000-0001-5995-6726
Yasuhiko TabataDepartment of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Dhiraj KumarDivision of Pediatric Dentistry, School of Dentistry, University of Minnesota, Minneapolis, MN 55812, USA.ORCID 0000-0002-1008-8638
Conrado AparicioMinnesota Dental Research Center for Biomaterials and Biomechanics, Department of Restorative Science, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-2969-6067
Isha MutrejaMinnesota Dental Research Center for Biomaterials and Biomechanics, Department of Restorative Science, University of Minnesota, Minneapolis, MN 55455, USA.

Funding

Army Medical Research Acquisition Activity MD 21702-5014Assistant Secretary of Defence for Health Affairs No W81XWH-20-1-0563Biotechnology and Biological Sciences Research Council BB/P017711/1Engineering and Physical Sciences Research Council EP/S017054/1Medical Research Council MR/R015651/1Medical Research Council MR/V00543X/1UK Regenerative Medicine Platform MR/R015651/1University of Minnesota's Office of Academic Clinical Affairs Faculty Research Development Grant OACA FRD #21.21
6 · The paper itself

Abstract

Musculoskeletal disorders are a significant burden on the global economy and public health. Hydrogels have significant potential for enhancing the repair of damaged and injured musculoskeletal tissues as cell or drug delivery systems. Hydrogels have unique physicochemical properties which make them promising platforms for controlling cell functions. Gelatin methacryloyl (GelMA) hydrogel in particular has been extensively investigated as a promising biomaterial due to its tuneable and beneficial properties and has been widely used in different biomedical applications. In this review, a detailed overview of GelMA synthesis, hydrogel design and applications in regenerative medicine is provided. After summarising recent progress in hydrogels more broadly, we highlight recent advances of GelMA hydrogels in the emerging fields of musculoskeletal drug delivery, involving therapeutic drugs (e.g., growth factors, antimicrobial molecules, immunomodulatory drugs and cells), delivery approaches (e.g., single-, dual-release system), and material design (e.g., addition of organic or inorganic materials, 3D printing). The review concludes with future perspectives and associated challenges for developing local drug delivery for musculoskeletal applications.

Indexed as

drug deliverygelatinGelMAhydrogelmusculoskeletal tissue

Identifiers

PMID35877383
PMCPMC9311920

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.