Evidence map›Paper›PMID 35877024›Full record

ArticleBehavior research methods2023

A new paradigm for investigating real-world social behavior and its neural underpinnings.

Arish Alreja, Michael J Ward, Qianli Ma, Brian E Russ, Stephan Bickel, Nelleke C Van Wouwe, Jorge A González-Martínez, Joseph S Neimat, Taylor J Abel, Anto Bagić and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Behavior research methods, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Arish AlrejaCenter for the Neural Basis of Cognition, Carnegie Mellon University and University of Pittsburgh, Pittsburgh, USA. aalreja@andrew.cmu.edu.ORCID 0000-0003-0173-376X
Michael J WardDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, USA.ORCID 0000-0001-8922-8332
Qianli MaLanguage Technologies Institute, Carnegie Mellon University, Pittsburgh, USA.ORCID 0000-0001-6932-0211
Brian E RussNathan Kline Institute for Psychiatric Research, Orangeburg, USA.ORCID 0000-0003-0320-1257
Stephan BickelDepartment of Neurosurgery and Neurology, Northwell Health, The Feinstein Institutes for Medical Research, Manhasset, USA.ORCID 0000-0001-5265-2447
Nelleke C Van WouweDepartment of Neurological Surgery, University of Louisville, Louisville, USA.ORCID 0000-0002-7839-0470
Jorge A González-MartínezDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, USA.ORCID 0000-0002-9936-7034
Joseph S NeimatDepartment of Neurological Surgery, University of Louisville, Louisville, USA.ORCID 0000-0002-1114-8938
Taylor J AbelCenter for the Neural Basis of Cognition, Carnegie Mellon University and University of Pittsburgh, Pittsburgh, USA.ORCID 0000-0002-5089-460X
Anto BagićDepartment of Neurology, University of Pittsburgh, Pittsburgh, USA.ORCID 0000-0002-6284-8336
Lisa S ParkerSchool of Public Health, University of Pittsburgh, Pittsburgh, USA.ORCID 0000-0003-2401-2359
R Mark RichardsonDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, USA.ORCID 0000-0003-2620-7387
Charles E SchroederNathan Kline Institute for Psychiatric Research, Orangeburg, USA.
Louis-Philippe MorencyLanguage Technologies Institute, Carnegie Mellon University, Pittsburgh, USA.ORCID 0000-0001-6376-7696
Avniel Singh GhumanCenter for the Neural Basis of Cognition, Carnegie Mellon University and University of Pittsburgh, Pittsburgh, USA.ORCID 0000-0003-1746-4656
University of Pittsburgh · USCarnegie Mellon University · USNathan Kline Institute for Psychiatric Research · USUniversity of Louisville · USHarvard University · USNorthwell Health · USUniversity of California, Los Angeles · US

Funding

Project 5: ComputationalP50MH109429 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI Robert Thomas Knight · 2017 to 2026
$25.3M
Defining Neuronal Circuits and Cellular Processes Underlying Resting fMRI SignalsR01MH111439 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI MILHAM, MICHAEL PETER, SCHROEDER, CHARLES E · 2016 to 2020
$5.1M
Active Social Vision: How the Brain Processes Visual Information During Natural Social PerceptionR01MH132225 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AVNIEL S GHUMAN, Louis-Philippe Morency · 2023 to 2026
$2.8M
Chemogenetic Dissection of Neuronal and Astrocytic Compartment of the BOLD SignalR01MH111429 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2016 to 2020
$2.7M
Inside the Social Perception Network: Dynamics, Connectivity, and StimulationR01MH107797 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GHUMAN, AVNIEL S · 2015 to 2019
$2.4M
Neurocognitive basis of attention and eye movement guidance in the real world scenesR21EY030297 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GHUMAN, AVNIEL S · 2019 to 2020
$430k
NEI NIH HHS R21 EY030297NIMH NIH HHS P50 MH109429NIMH NIH HHS R01 MH107797NIMH NIH HHS R01 MH111429NIMH NIH HHS R01 MH111439NIMH NIH HHS R01 MH132225
6 · The paper itself

Abstract

Eye tracking and other behavioral measurements collected from patient-participants in their hospital rooms afford a unique opportunity to study natural behavior for basic and clinical translational research. We describe an immersive social and behavioral paradigm implemented in patients undergoing evaluation for surgical treatment of epilepsy, with electrodes implanted in the brain to determine the source of their seizures. Our studies entail collecting eye tracking with other behavioral and psychophysiological measurements from patient-participants during unscripted behavior, including social interactions with clinical staff, friends, and family in the hospital room. This approach affords a unique opportunity to study the neurobiology of natural social behavior, though it requires carefully addressing distinct logistical, technical, and ethical challenges. Collecting neurophysiological data synchronized to behavioral and psychophysiological measures helps us to study the relationship between behavior and physiology. Combining across these rich data sources while participants eat, read, converse with friends and family, etc., enables clinical-translational research aimed at understanding the participants' disorders and clinician-patient interactions, as well as basic research into natural, real-world behavior. We discuss data acquisition, quality control, annotation, and analysis pipelines that are required for our studies. We also discuss the clinical, logistical, and ethical and privacy considerations critical to working in the hospital setting.

Indexed as

BrainSocial BehaviorHumansPrivacy

Identifiers

PMID35877024
PMCPMC10841340
OpenAlexW4287448036

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.