Evidence map›Paper›PMID 35876794›Full record

ArticleJournal of the American Chemical Society2022

A Single-Component Luminescent Biosensor for the SARS-CoV-2 Spike Protein.

Matthew Ravalin, Heegwang Roh, Rahul Suryawanshi, G Renuka Kumar, John E Pak, Melanie Ott, Alice Y Ting

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  8. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Rahul SuryawanshiGladstone Institutes, San Francisco, California 94158, United States.
G Renuka KumarGladstone Institutes, San Francisco, California 94158, United States.
John E PakChan Zuckerberg Biohub, San Francisco, California 94158, United States.
Melanie OttGladstone Institutes, San Francisco, California 94158, United States.
Alice Y TingChan Zuckerberg Biohub, San Francisco, California 94158, United States.ORCID 0000-0002-8277-5226

Funding

Targeting Viroporins and Coronavirus M ProteinU19AI171110 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nevan J Krogan · 2022 to 2026
$103.4M
INSTITUTIONAL TRAINING GRANT IN GENOME SCIENCET32HG000044 · NHGRI · STANFORD UNIVERSITY · PI MICHAEL P. SNYDER · 1995 to 2026
$32.2M
COMPUTATIONAL METHODS FOR PROTEOMIC ANALYSISK22HG000044 · NHGRI · UNIVERSITY OF UTAH · PI GIDDINGS, MORGAN CORINNE · 2000 to 2005
$1.3M
NHGRI NIH HHS K22 HG000044NHGRI NIH HHS T32 HG000044NIAID NIH HHS U19 AI171110
6 · The paper itself

Abstract

Many existing protein detection strategies depend on highly functionalized antibody reagents. A simpler and easier to produce class of detection reagent is highly desirable. We designed a single-component, recombinant, luminescent biosensor that can be expressed in laboratory strains of

Indexed as

Biosensing TechniquesCOVID-19HumansSARS-CoV-2Spike Glycoprotein, CoronavirusSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2

Identifiers

PMID35876794
PMCPMC10580660

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.