Evidence map›Paper›PMID 35876530›Full record

ArticlemSphere2022

Serological Analysis Identifies Consequential B Cell Epitopes on the Flexible Linker and C-Terminus of Decorin Binding Protein A (DbpA) from Borrelia burgdorferi.

Elaheh Movahed, David J Vance, Dylan Ehrbar, Greta Van Slyke, Jennifer Yates, Karen Kullas, Michael Rudolph, Nicholas J Mantis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Elaheh Movahed *Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
David J Vance *Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, USA.ORCID 0000-0002-9913-7722
Dylan EhrbarDivision of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, USA.ORCID 0000-0001-7872-3338
Greta Van SlykeDivision of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, USA.ORCID 0000-0003-2646-3030
Jennifer YatesDivision of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, USA.ORCID 0000-0001-8841-9401
Karen KullasDivision of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Michael RudolphNew York Structural Biology Centergrid.422632.3, New York, New York, USA.
Nicholas J MantisDivision of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, USA.ORCID 0000-0002-5083-8640
New York State Department of Health · USNew York Structural Biology Center · US

Funding

Tickborne Disease: B cell epitope discovery and mechanisms of antibody Protection75N93019C00040 · NIAID · NYSDOH/HEALTH RESEARCH, INC. · PI MANTIS, NICHOLAS J. · 2019 to 2023
$10.3M
NIAID NIH HHS 75N93019C00040
6 · The paper itself

Abstract

Decorin binding protein A (DbpA) is a surface adhesin of Borrelia burgdorferi, the causative agent of Lyme disease. While DbpA is one of the most immunogenic of B. burgdorferi's nearly 100 lipoproteins, the B cell epitopes on DbpA recognized by humans following B. burgdorferi infection have not been fully elucidated. In this report we profiled ~270 B. burgdorferi-seropositive human serum samples for IgM and IgG reactivity with a tiled DbpA 18-mer peptide array derived from B. burgdorferi

Indexed as

Borrelia burgdorferiLyme DiseaseBacterial ProteinsDecorinEpitopes, B-LymphocyteHumansImmunoglobulin GImmunoglobulin MBacterial ProteinsDecorinEpitopes, B-LymphocyteImmunoglobulin GImmunoglobulin Mantibodyantibody functionBorrelia burgdorferiepitopeLyme diseasevaccine

Identifiers

PMID35876530
PMCPMC9429923
OpenAlexW4287377246

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.