Evidence map›Paper›PMID 35876420›Full record

ArticleJournal of the American Heart Association2022

Fibroblast Growth Factor 23 and Risk of New Onset Heart Failure With Preserved or Reduced Ejection Fraction: The PREVEND Study.

S Heleen Binnenmars, Georgette E Hoogslag, Stanley M H Yeung, Frank P Brouwers, Stephan J L Bakker, Wiek H van Gilst, Ron T Gansevoort, Gerjan Navis, Adriaan A Voors, Martin H de Borst

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. FGF23 - A hormone produced by bone and has many faces.Reviews in endocrine & metabolic disorders · 2026
    Review
  3. Article
  4. Observational
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  6. Review
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  8. Review
  9. Article
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

S Heleen BinnenmarsDepartment of Internal Medicine, Division of Nephrology University of Groningen, University Medical Center Groningen Groningen The Netherlands.ORCID 0000-0002-3305-9485
Georgette E HoogslagDepartment of Internal Medicine, Division of Nephrology University of Groningen, University Medical Center Groningen Groningen The Netherlands.ORCID 0000-0002-8262-3089
Stanley M H YeungDepartment of Internal Medicine, Division of Nephrology University of Groningen, University Medical Center Groningen Groningen The Netherlands.ORCID 0000-0002-1531-7516
Frank P BrouwersDepartment of Cardiology University of Groningen, University Medical Center Groningen Groningen The Netherlands.ORCID 0000-0003-0518-2387
Stephan J L BakkerDepartment of Internal Medicine, Division of Nephrology University of Groningen, University Medical Center Groningen Groningen The Netherlands.ORCID 0000-0003-3356-6791
Wiek H van GilstDepartment of Cardiology University of Groningen, University Medical Center Groningen Groningen The Netherlands.ORCID 0000-0003-2968-8585
Ron T GansevoortDepartment of Internal Medicine, Division of Nephrology University of Groningen, University Medical Center Groningen Groningen The Netherlands.
Gerjan NavisDepartment of Internal Medicine, Division of Nephrology University of Groningen, University Medical Center Groningen Groningen The Netherlands.
Adriaan A VoorsDepartment of Cardiology University of Groningen, University Medical Center Groningen Groningen The Netherlands.ORCID 0000-0002-5417-4415
Martin H de BorstDepartment of Internal Medicine, Division of Nephrology University of Groningen, University Medical Center Groningen Groningen The Netherlands.ORCID 0000-0002-4127-8733
University Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background The role of fibroblast growth factor 23 (FGF23) in the development of new-onset heart failure (HF) with reduced (HFrEF) or preserved ejection fraction (HFpEF) in the general population is unknown. Therefore, we set out to investigate associations of C-terminal FGF23 with development of new-onset HF and, more specifically, with HFrEF or HFpEF in a large, prospective, population-based cohort. Methods and Results We studied 6830 participants (aged 53.8±12.1 years; 49.7% men; estimated glomerular filtration rate, 93.1±15.7 mL/min per 1.73 m

Indexed as

Fibroblast Growth Factor-23Heart FailureAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrognosisProspective StudiesRisk FactorsStroke VolumeFGF23 protein, humanFibroblast Growth Factor-23fibroblast growth factor 23general populationheart failure with preserved ejection fractionheart failure with reduced ejection fraction

Identifiers

PMID35876420
PMCPMC9375507
OpenAlexW4287377779

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.