ArticlePsychological medicine2023
Brain age and cognitive functioning in first-episode bipolar disorder.
Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- BrainAGE, brain health, and mental disorders: A systematic review.Neuroscience and biobehavioral reviews · 2024Pooled it
- Influence of BDNF rs10835210 on right parahippocampal volume and its related cognitive function in first- and multiple-episode bipolar disorder.BMC psychiatry · 2026Article
- Brain Age Disparities in Psychosis Across DSM Diagnoses and B-SNIP Biotypes.Schizophrenia bulletin · 2026Article
- Brain age gap is associated with cognitive abilities in captive chimpanzees.Scientific reports · 2025Article
- Individual-level brain phenotypes in first-episode mania: normative modelling of brain morphometry and brainAGE.BJPsych open · 2025Article
- Association between GRIN2B DNA methylation and cognitive impairment: a cross-sectional study of patients with bipolar depression.Frontiers in psychiatry · 2025Article
- Mediating role of brain aging in the effect of white matter hyperintensities on post-stroke aphasia severity.Frontiers in aging neuroscience · 2025Article
- The causal mediating effect of smoking on the relationship between irritability and bipolar disorder: A two-step Mendelian randomization study.Tobacco induced diseases · 2025Article
- Functional Alterations in Patients with Bipolar Disorder and Their Unaffected First-Degree Relatives: Insight from Genetic, Epidemiological, and Neuroimaging Data.Neuropsychiatric disease and treatment · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is significant heterogeneity in cognitive function in patients with bipolar I disorder (BDI); however, there is a dearth of research into biological mechanisms that might underlie cognitive heterogeneity, especially at disease onset. To this end, this study investigated the association between accelerated or delayed age-related brain structural changes and cognition in early-stage BDI.
methodsFirst episode patients with BDI (
resultsPatients in the lowest (delayed) tertile of brainPAD values (brainPAD range -17.9 to -6.5 years) had significantly lower global cognitive scores (
conclusionThese results provide evidence linking cognitive dysfunction in the early stage of BDI to apparent delay in typical age-related brain changes. Further studies are required to assess how age-related brain changes and cognitive functioning evolve over time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.